(1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Base Information

Chemical Name:(1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate
CAS No.:1319211-95-4
Molecular Formula:C₁₅H₁₅IN₂O₂
Molecular Weight:382.201
Hs Code.:

Synonyms:(1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Suppliers and Price of (1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of (1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

There total 4 articles about (1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1242440-98-7
(1S,2S)-ethyl 2-(4-(1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

: 1319211-95-4
(1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: With N-iodo-succinimide; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ml4000996

Reference yield:

: 875479-34-8
ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1319211-95-4
(1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

1.2: 1 h / 20 °C

1.3: 4 h / Reflux

2.1: hydrogenchloride / methanol / 2 h / Reflux

3.1: N-iodo-succinimide / dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; ethylmagnesium bromide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ml4000996

Reference yield:

: 1242440-99-8
(1S,2S)-ethyl 2-(4-(1-trityl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

: 1319211-95-4
(1S,2S)-ethyl 2-(4-(5-iodo-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol / 2 h / Reflux

2: N-iodo-succinimide / dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; In methanol; dichloromethane;
DOI:10.1021/ml4000996