(S)-N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-N'-[2-(9-fluorenylmethoxycarbonyl)amino-4-phenylbutylcarbonyl]methylisothiourea

Base Information

Chemical Name:(S)-N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-N'-[2-(9-fluorenylmethoxycarbonyl)amino-4-phenylbutylcarbonyl]methylisothiourea
CAS No.:535952-65-9
Molecular Formula:C₄₂H₄₇N₃O₁₂S
Molecular Weight:817.914
Hs Code.:

Synonyms:(S)-N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-N'-[2-(9-fluorenylmethoxycarbonyl)amino-4-phenylbutylcarbonyl]methylisothiourea

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Chemical Property of (S)-N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-N'-[2-(9-fluorenylmethoxycarbonyl)amino-4-phenylbutylcarbonyl]methylisothiourea

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Technology Process of (S)-N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-N'-[2-(9-fluorenylmethoxycarbonyl)amino-4-phenylbutylcarbonyl]methylisothiourea

There total 2 articles about (S)-N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-N'-[2-(9-fluorenylmethoxycarbonyl)amino-4-phenylbutylcarbonyl]methylisothiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 219967-74-5
(S)-3-(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)-5-phenylpentanoic acid

: 535952-60-4
N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)methylisothiourea

: 535952-65-9
(S)-N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-N'-[2-(9-fluorenylmethoxycarbonyl)amino-4-phenylbutylcarbonyl]methylisothiourea

Guidance literature:: With i-PrNEt; benzotriazol-1-ol; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl acetamide; at 20 ℃; for 24h;
DOI:10.1055/s-2003-36815

Reference yield:

: N-(2,3,4,6-tetra-O-acetyl-D-glucopyranosyl)-N,N'-bis(tert-butoxycarbonyl)methylisothiourea

: 535952-65-9
(S)-N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-N'-[2-(9-fluorenylmethoxycarbonyl)amino-4-phenylbutylcarbonyl]methylisothiourea

Guidance literature:: Multi-step reaction with 2 steps

1: anisole; TFA / CH₂Cl₂ / 0.25 h / 0 °C

2: 67 percent / N-hydroxybenzotriazole; 1,3-diisopropylcarbodiimide; i-PrNEt / N,N-dimethyl-acetamide; CH₂Cl₂ / 24 h / 20 °C

With i-PrNEt; benzotriazol-1-ol; methoxybenzene; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1055/s-2003-36815