7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-3H-5-oxa-3-aza-cyclopenta[a]naphthalen-4-one

Base Information

• Chemical Name: 7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-3H-5-oxa-3-aza-cyclopenta[a]naphthalen-4-one
• CAS No.: 895632-73-2
• Molecular Formula: C₃₉H₃₉NO₈
• Molecular Weight: 649.741

Synonyms:7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-3H-5-oxa-3-aza-cyclopenta[a]naphthalen-4-one

Chemical Property of 7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-3H-5-oxa-3-aza-cyclopenta[a]naphthalen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-3H-5-oxa-3-aza-cyclopenta[a]naphthalen-4-one

There total 8 articles about 7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-3H-5-oxa-3-aza-cyclopenta[a]naphthalen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-4-oxo-3,4-dihydro-5-oxa-3-aza-cyclopenta[a]naphthalene-2-carboxylic acid (895632-72-1) → 7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-3H-5-oxa-3-aza-cyclopenta[a]naphthalen-4-one (895632-73-2)

Guidance literature:

With quinoline; copper(I) oxide; at 220 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2006.03.121

Reference yield:

1-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-(3-isopropoxy-4-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester (895632-68-5) → 7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-3H-5-oxa-3-aza-cyclopenta[a]naphthalen-4-one (895632-73-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 90 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 20 h / Heating

2.1: 93 percent / cc.HCl / methanol / 2 h / Heating

3.1: aq. KOH / ethanol / 3 h / Heating

3.2: 77 percent / p-TsOH / CH₂Cl₂ / 1 h / Heating

4.1: 96 percent / Cu₂O; quinoline / 0.17 h / 220 °C

With quinoline; copper(I) oxide; hydrogenchloride; potassium hydroxide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; 1.1: Suzuki-Miyaura coupling;

DOI:10.1016/j.tetlet.2006.03.121

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-3H-5-oxa-3-aza-cyclopenta[a]naphthalen-4-one (895632-73-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 91 percent / NaHCO₃ / acetonitrile / 2.5 h / Heating

2.1: 85 percent / NaH / tetrahydrofuran / 4.5 h / Heating

3.1: 92 percent / pyridine / 2 h / 0 °C

4.1: 80 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 5 h / Heating

5.1: 90 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 20 h / Heating

6.1: 93 percent / cc.HCl / methanol / 2 h / Heating

7.1: aq. KOH / ethanol / 3 h / Heating

7.2: 77 percent / p-TsOH / CH₂Cl₂ / 1 h / Heating

8.1: 96 percent / Cu₂O; quinoline / 0.17 h / 220 °C

With quinoline; copper(I) oxide; hydrogenchloride; potassium hydroxide; sodium hydride; sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; methanol; ethanol; acetonitrile; 2.1: Hinsberg-type pyrrole synthesis / 4.1: Suzuki-Miyaura coupling / 5.1: Suzuki-Miyaura coupling;

DOI:10.1016/j.tetlet.2006.03.121

upstream raw materials:

7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-4-oxo-3,4-dihydro-5-oxa-3-aza-cyclopenta[a]naphthalene-2-carboxylic acid

1-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-(3-isopropoxy-4-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

7-benzyloxy-3-[2-(3,4-dimethoxy-phenyl)-ethyl]-1-(3-isopropoxy-4-methoxy-phenyl)-8-methoxy-4-oxo-3,4-dihydro-5-oxa-3-aza-cyclopenta[a]naphthalene-2-carboxylic acid methyl ester

3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Downstream raw materials:

3-benzyloxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-7,8-dihydro-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

3-hydroxy-13-(3-isopropoxy-4-methoxy-phenyl)-2,10,11-trimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

20-benzyl-13-isopropyllamellarin α

14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6-oxo-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-3-yl 2,2,2-trichloroethyl sulfate

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