Technology Process of 4,6-dimethoxy-2-(propen-1-yl)-benzoic acid [4-(2-but-3-enyl-[1,3]dithian-2-yl)-1-methyl-butyl]ester
There total 8 articles about 4,6-dimethoxy-2-(propen-1-yl)-benzoic acid [4-(2-but-3-enyl-[1,3]dithian-2-yl)-1-methyl-butyl]ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium chloride;
tris(dibenzylideneacetone)dipalladium (0); trifuran-2-yl-phosphane;
In
1-methyl-pyrrolidin-2-one;
at 60 ℃;
for 24h;
DOI:10.1016/S0040-4020(99)00302-6
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 87 percent / BF3*Et2O / methanol; CHCl3 / 4 h / 25 °C
2.1: sec-BuLi / cyclohexane; tetrahydrofuran / 4 h / -15 °C
2.2: 85 percent / 16 h
3.1: 62 percent / PCC / CH2Cl2 / 5 h / 25 °C
4.1: 97 percent / diethyl ether / 14 h / -30 °C
5.1: 84 percent / EtOOC-N=N-COOEt; PPh3 / diethyl ether / 5 h
6.1: 91 percent / pyridine / CH2Cl2 / 0 - 25 °C
7.1: 60 percent / LiCl / Pd2(dba)3/tris(2-furyl)phosphine / 1-methyl-pyrrolidin-2-one / 24 h / 60 °C
With
pyridine; boron trifluoride diethyl etherate; sec.-butyllithium; triphenylphosphine; pyridinium chlorochromate; lithium chloride; diethylazodicarboxylate;
tris(dibenzylideneacetone)dipalladium (0); trifuran-2-yl-phosphane;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane; chloroform; cyclohexane;
1.1: Cyclization / 2.1: Metallation / 2.2: Substitution / 3.1: Oxidation / 4.1: Grignard reaction / 5.1: Esterification / 6.1: Esterification / 7.1: Stille coupling reaction;
DOI:10.1016/S0040-4020(99)00302-6
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / NaOMe / methanol / 12 h / 120 °C / 30400 Torr
2: 84 percent / EtOOC-N=N-COOEt; PPh3 / diethyl ether / 5 h
3: 91 percent / pyridine / CH2Cl2 / 0 - 25 °C
4: 60 percent / LiCl / Pd2(dba)3/tris(2-furyl)phosphine / 1-methyl-pyrrolidin-2-one / 24 h / 60 °C
With
pyridine; sodium methylate; triphenylphosphine; lithium chloride; diethylazodicarboxylate;
tris(dibenzylideneacetone)dipalladium (0); trifuran-2-yl-phosphane;
In
1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane;
1: Kolbe-Schmitt reaction / 2: Esterification / 3: Esterification / 4: Stille coupling reaction;
DOI:10.1016/S0040-4020(99)00302-6
