2-(o,p-dicyanophenyl)-2,3-dimethyl-3-nitrobutane

Base Information

• Chemical Name: 2-(o,p-dicyanophenyl)-2,3-dimethyl-3-nitrobutane
• CAS No.: 72206-83-8
• Molecular Formula: C₁₄H₁₅N₃O₂
• Molecular Weight: 257.292
• Mol file: 72206-83-8.mol

Synonyms:2-(o,p-dicyanophenyl)-2,3-dimethyl-3-nitrobutane

Chemical Property of 2-(o,p-dicyanophenyl)-2,3-dimethyl-3-nitrobutane

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(o,p-dicyanophenyl)-2,3-dimethyl-3-nitrobutane

There total 8 articles about 2-(o,p-dicyanophenyl)-2,3-dimethyl-3-nitrobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

lithium 2-nitropropane (3958-63-2) + o,p-dicyano-α-nitrocumene (123871-55-6) → 2-(o,p-dicyanophenyl)-2,3-dimethyl-3-nitrobutane (72206-83-8)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; for 5h; Ambient temperature; Irradiation;

DOI:10.1016/0040-4020(89)80129-2

Reference yield: 84.0%

lithium 2-nitropropane (3958-63-2) + o,p-dicyano-α-phenylsulfonylcumene (72214-06-3) → 2-(o,p-dicyanophenyl)-2,3-dimethyl-3-nitrobutane (72206-83-8)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; at 25 ℃; for 5h; Irradiation;

DOI:10.1021/jo01290a036

Reference yield:

4-nitroisophthalic acid (4315-09-7) → 2-(o,p-dicyanophenyl)-2,3-dimethyl-3-nitrobutane (72206-83-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 56 percent / p-toluenesulfonamide, PCl₅ / 0.5 h / 200 - 205 °C

2: 76 percent / dimethylsulfoxide / 1.5 h / Ambient temperature

3: 88 percent / dimethylformamide / 0.5 h / Irradiation

4: 87 percent / 30percent H₂O₂ / acetic acid; H₂O / 24 h / Ambient temperature

5: 84 percent / hexamethylphosphoric acid triamide / 5 h / Ambient temperature; Irradiation

With phosphorus pentachloride; dihydrogen peroxide; toluene-4-sulfonamide; In N,N,N,N,N,N-hexamethylphosphoric triamide; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(89)80129-2

upstream raw materials:

lithium 2-nitropropane

o,p-dicyano-α-phenylsulfonylcumene

o,p-dicyano-α-nitrocumene

2,4-dimethylnitrobenzene

Refernces

• 1、 Kornblum, Nathan,Fifolt, Michael J.. "The Cyano Group as a Facilitator of Electron-Transfer Chain-Substitution Processes". . p. 360 - 361. Retrieved 2007/10/02.