(S)-methyl (4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

Base Information

Chemical Name:(S)-methyl (4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-2,3-dihydro-1H-inden-1-yl)carbamate
CAS No.:1307869-45-9
Molecular Formula:C₂₄H₂₃N₃O₃S
Molecular Weight:433.531
Hs Code.:

Synonyms:(S)-methyl (4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

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Chemical Property of (S)-methyl (4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

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Technology Process of (S)-methyl (4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

There total 8 articles about (S)-methyl (4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-2,3-dihydro-1H-inden-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1307869-28-8
(S)-5-(5-(1-amino-2,3-dihydro-1H-inden-4-yl)thiazol-2-yl)-2-isopropoxybenzonitrile hydrochloride

: 79-22-1
methyl chloroformate

: 1307869-45-9
(S)-methyl (4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1307231-21-5
(S)-tert-butyl 4-bromo-2,3-dihydro-1H-inden-1-ylcarbamate

: 1307869-45-9
(S)-methyl (4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 12 h / 80 °C / Inert atmosphere

3: isopropyl alcohol / 4 h / 60 °C

4: hydrogenchloride / 1,4-dioxane / 2.5 h / 55 °C

5: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; isopropyl alcohol;

Reference yield:

: (S)-tert-butyl (4-(2-(3-cyano-4-fluorophenyl)thiazol-5-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

: 1307869-45-9
(S)-methyl (4-(2-(3-cyano-4-isopropoxyphenyl)thiazol-5-yl)-2,3-dihydro-1H-inden-1-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 4 h / 60 °C

2: hydrogenchloride / 1,4-dioxane / 2.5 h / 55 °C

3: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane; isopropyl alcohol;