(R)-N-((1S,2R)-2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide

Base Information

Chemical Name:(R)-N-((1S,2R)-2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide
CAS No.:1574475-19-6
Molecular Formula:C₂₀H₃₁NO₂S
Molecular Weight:349.538
Hs Code.:

Synonyms:(R)-N-((1S,2R)-2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide

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Chemical Property of (R)-N-((1S,2R)-2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide

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Technology Process of (R)-N-((1S,2R)-2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide

There total 10 articles about (R)-N-((1S,2R)-2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1574475-01-6
C₂₀H₂₉NO₂S

: 1574475-19-6
(R)-N-((1S,2R)-2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide

: (R)-N-(2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide

Guidance literature:: With samarium diiodide; In tetrahydrofuran; at 20 ℃; Overall yield = 63 %; stereoselective reaction; Inert atmosphere;
DOI:10.1080/00397911.2013.841938

Reference yield:

: C₁₂H₁₇NO₄

: 1574475-19-6
(R)-N-((1S,2R)-2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide

: (R)-N-(2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / methanol / Molecular sieve; Reflux

2: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3: hydrogenchloride / water / 0.25 h / 20 °C / Inert atmosphere

4: potassium hydrogensulfate / toluene / 18 h / 20 °C

5: samarium diiodide / tetrahydrofuran / 20 °C / Inert atmosphere

With hydrogenchloride; potassium hydrogensulfate; n-butyllithium; samarium diiodide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1080/00397911.2013.841938

Reference yield:

: C₁₈H₂₆O₃

: 1574475-19-6
(R)-N-((1S,2R)-2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide

: (R)-N-(2-hydroxy-2-cyclohexanyl-1,2,3,4-tetrahydronaphthalen-1-yl)tert-butylsulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 0.25 h / 20 °C / Inert atmosphere

2: potassium hydrogensulfate / toluene / 18 h / 20 °C

3: samarium diiodide / tetrahydrofuran / 20 °C / Inert atmosphere

With hydrogenchloride; potassium hydrogensulfate; samarium diiodide; In tetrahydrofuran; water; toluene;
DOI:10.1080/00397911.2013.841938