N-<4-<4-(4-methyl-1-piperidinyl)-1,4-dioxybutyl>phenyl>methanesulfonamide

Base Information

• Chemical Name: N-<4-<4-(4-methyl-1-piperidinyl)-1,4-dioxybutyl>phenyl>methanesulfonamide
• CAS No.: 130350-67-3
• Molecular Formula: C₁₇H₂₄N₂O₄S
• Molecular Weight: 352.455

Synonyms:N-<4-<4-(4-methyl-1-piperidinyl)-1,4-dioxybutyl>phenyl>methanesulfonamide

Chemical Property of N-<4-<4-(4-methyl-1-piperidinyl)-1,4-dioxybutyl>phenyl>methanesulfonamide

Chemical Property:

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Technology Process of N-<4-<4-(4-methyl-1-piperidinyl)-1,4-dioxybutyl>phenyl>methanesulfonamide

There total 2 articles about N-<4-<4-(4-methyl-1-piperidinyl)-1,4-dioxybutyl>phenyl>methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phenylmethanesulfonamide (1197-22-4) → N-<4-<4-(4-methyl-1-piperidinyl)-1,4-dioxybutyl>phenyl>methanesulfonamide (130350-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 19.1 g / AlCl₃ / CS₂ / 24 h / 20 - 55 °C

2: 1.) 1,1-carbonyldiimidazole / 1.) THF, RT, 1 h, 2.) a) RT, 18 h, b) 50 deg C, 2 h

With aluminium trichloride; 1,1'-carbonyldiimidazole; In carbon disulfide;

DOI:10.1021/jm00105a048

Reference yield:

4-methylpiperidin (626-58-4) + 4-((methanesulfonyl)amino)-γ-oxobenzenebutanoic acid (100632-57-3) → N-<4-<4-(4-methyl-1-piperidinyl)-1,4-dioxybutyl>phenyl>methanesulfonamide (130350-67-3)

Guidance literature:

With 1,1'-carbonyldiimidazole; Yield given. Multistep reaction; 1.) THF, RT, 1 h, 2.) a) RT, 18 h, b) 50 deg C, 2 h;

DOI:10.1021/jm00105a048

Reference yield: 48.3%

N-<4-<4-(4-methyl-1-piperidinyl)-1,4-dioxybutyl>phenyl>methanesulfonamide (130350-67-3) → N-{4-[1-Hydroxy-4-(4-methyl-piperidin-1-yl)-butyl]-phenyl}-methanesulfonamide (130350-63-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jm00105a048

upstream raw materials:

4-methylpiperidin

4-((methanesulfonyl)amino)-γ-oxobenzenebutanoic acid

N-phenylmethanesulfonamide

Downstream raw materials:

N-{4-[1-Hydroxy-4-(4-methyl-piperidin-1-yl)-butyl]-phenyl}-methanesulfonamide

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