5-(Biphenyl-4-ylmethoxy)-2-phenyl-4-trifluoromethyl-oxazole

Base Information

• Chemical Name: 5-(Biphenyl-4-ylmethoxy)-2-phenyl-4-trifluoromethyl-oxazole
• CAS No.: 126745-85-5
• Molecular Formula: C₂₃H₁₆F₃NO₂
• Molecular Weight: 395.381
• Mol file: 126745-85-5.mol

Synonyms:5-(Biphenyl-4-ylmethoxy)-2-phenyl-4-trifluoromethyl-oxazole

Chemical Property of 5-(Biphenyl-4-ylmethoxy)-2-phenyl-4-trifluoromethyl-oxazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-(Biphenyl-4-ylmethoxy)-2-phenyl-4-trifluoromethyl-oxazole

There total 1 articles about 5-(Biphenyl-4-ylmethoxy)-2-phenyl-4-trifluoromethyl-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-Fluoro-4-trifluoromethyl-2-phenyloxazole (70276-69-6) + biphenyl-4-yl methanol (3597-91-9) → 5-(Biphenyl-4-ylmethoxy)-2-phenyl-4-trifluoromethyl-oxazole (126745-85-5)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane;

DOI:10.1055/s-1989-27408

Reference yield: 8.0%

5-(Biphenyl-4-ylmethoxy)-2-phenyl-4-trifluoromethyl-oxazole (126745-85-5) → 4-Biphenyl-4-ylmethyl-2-phenyl-4-trifluoromethyl-4H-oxazol-5-one (126745-99-1)

Guidance literature:

DOI:10.1055/s-1989-27408

Reference yield:

5-(Biphenyl-4-ylmethoxy)-2-phenyl-4-trifluoromethyl-oxazole (126745-85-5) → 2-Benzoylamino-2-biphenyl-4-ylmethyl-3,3,3-trifluoro-propionic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 8 percent

2: 1 N aq. HCl / tetrahydrofuran / 2 h / 50 °C

With hydrogenchloride; In tetrahydrofuran;

DOI:10.1055/s-1989-27408

upstream raw materials:

5-Fluoro-4-trifluoromethyl-2-phenyloxazole

biphenyl-4-yl methanol

Downstream raw materials:

4-Biphenyl-4-ylmethyl-2-phenyl-4-trifluoromethyl-4H-oxazol-5-one