Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-4-methyl-, (4R-cis)- (9CI)

Base Information

Chemical Name:Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-4-methyl-, (4R-cis)- (9CI)
CAS No.:143393-98-0
Molecular Formula:C₈H₁₄N₂O
Molecular Weight:154.212
Hs Code.:
Mol file:143393-98-0.mol

Synonyms:Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-4-methyl-, (4R-cis)- (9CI);(4R,8AR)-4-METHYLHEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE

Suppliers and Price of Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-4-methyl-, (4R-cis)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-4-methyl-, (4R-cis)- (9CI)

Chemical Property:

PSA：32.34000
LogP:0.23580

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-4-methyl-, (4R-cis)- (9CI)

There total 2 articles about Pyrrolo[1,2-a]pyrazin-1(2H)-one, hexahydro-4-methyl-, (4R-cis)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 143317-63-9
(R)-1-((E)-1-Methyl-2-nitro-vinyl)-pyrrolidine-2-carboxylic acid methyl ester

: 143393-98-0
(2S,6R)-(+)-2-Methyl-1,4-diazabicyclo<4.3.0>nonan-5-one

: 143394-82-5
(2R,6R)-(+)-2-Methyl-1,4-diazabicyclo<4.3.0>nonan-5-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 12h; under 2327.2 Torr;
DOI:10.1016/S0040-4020(01)81592-1

Reference yield:

: 114376-47-5
D-N-acetylproline methyl ester

: 143393-98-0
(2S,6R)-(+)-2-Methyl-1,4-diazabicyclo<4.3.0>nonan-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Me₂SO₄; 2) Et₃N / 1) 80 deg C; 2) CHCl₃, room temp., 12 h

2: 37 percent / H₂ / 10percent Pd-C / methanol / 12 h / 2327.2 Torr

With hydrogen; triethylamine; dimethyl sulfate; palladium on activated charcoal; In methanol;
DOI:10.1016/S0040-4020(01)81592-1