benzyl 3-(3-(((2,2-dimethyl-4,13-dioxo-3,8,11,17-tetraoxa-5,14-diazanonadecan-19-yl)oxy)sulfonyl)benzamido)propanoate

Base Information

• Chemical Name: benzyl 3-(3-(((2,2-dimethyl-4,13-dioxo-3,8,11,17-tetraoxa-5,14-diazanonadecan-19-yl)oxy)sulfonyl)benzamido)propanoate
• CAS No.: 1365253-84-4
• Molecular Formula: C₃₂H₄₅N₃O₁₂S
• Molecular Weight: 695.788
• Mol file: 1365253-84-4.mol

Synonyms:benzyl 3-(3-(((2,2-dimethyl-4,13-dioxo-3,8,11,17-tetraoxa-5,14-diazanonadecan-19-yl)oxy)sulfonyl)benzamido)propanoate

Chemical Property of benzyl 3-(3-(((2,2-dimethyl-4,13-dioxo-3,8,11,17-tetraoxa-5,14-diazanonadecan-19-yl)oxy)sulfonyl)benzamido)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 3-(3-(((2,2-dimethyl-4,13-dioxo-3,8,11,17-tetraoxa-5,14-diazanonadecan-19-yl)oxy)sulfonyl)benzamido)propanoate

There total 5 articles about benzyl 3-(3-(((2,2-dimethyl-4,13-dioxo-3,8,11,17-tetraoxa-5,14-diazanonadecan-19-yl)oxy)sulfonyl)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

benzyl 3-(3-(chlorosulfonyl)benzamido)propanoate (1365253-83-3) + C15H30N2O7 (1365253-91-3) → benzyl 3-(3-(((2,2-dimethyl-4,13-dioxo-3,8,11,17-tetraoxa-5,14-diazanonadecan-19-yl)oxy)sulfonyl)benzamido)propanoate (1365253-84-4)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.916667h;

DOI:10.1002/anie.201106995

Reference yield:

3-chlorosulfonylbenzoyl dichloride (4052-92-0) → benzyl 3-(3-(((2,2-dimethyl-4,13-dioxo-3,8,11,17-tetraoxa-5,14-diazanonadecan-19-yl)oxy)sulfonyl)benzamido)propanoate (1365253-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.92 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1002/anie.201106995

Reference yield:

tert-butyl(2,2-dimethyl-11-oxo-3,3-diphenyl-4,7,13,16-tetraoxa-10-aza-3-silaoctadecan-18-yl)carbamate (1365253-82-2) → benzyl 3-(3-(((2,2-dimethyl-4,13-dioxo-3,8,11,17-tetraoxa-5,14-diazanonadecan-19-yl)oxy)sulfonyl)benzamido)propanoate (1365253-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.92 h / 20 °C

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.92 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.201106995

upstream raw materials:

tert-butyl(2,2-dimethyl-11-oxo-3,3-diphenyl-4,7,13,16-tetraoxa-10-aza-3-silaoctadecan-18-yl)carbamate

benzyl 3-(3-(chlorosulfonyl)benzamido)propanoate

C₁₅H₃₀N₂O₇

3-chlorosulfonylbenzoyl dichloride