Technology Process of 2-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acetaldehyde
There total 6 articles about 2-(2-(tert-butyldimethylsilyloxy)-3,5,6-trimethoxyphenyl)acetaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium periodate; osmium(VIII) oxide;
In
diethyl ether; water; tert-butyl alcohol;
at 20 ℃;
for 40h;
DOI:10.1016/j.tet.2012.04.024
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / acetone / 20 h / Reflux
2: 0.5 h / 190 °C / Microwave irradiation; neat (no solvent)
3: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C
4: sodium periodate; osmium(VIII) oxide / diethyl ether; water; tert-butyl alcohol / 40 h / 20 °C
With
1H-imidazole; sodium periodate; osmium(VIII) oxide; potassium carbonate;
In
diethyl ether; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
2: Claisen rearrangement / 4: Lemieux-Johnson oxidative cleavage;
DOI:10.1016/j.tet.2012.04.024
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C
2: potassium hydroxide / ethanol / 2 h
3: potassium carbonate / acetone / 20 h / Reflux
4: 0.5 h / 190 °C / Microwave irradiation; neat (no solvent)
5: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C
6: sodium periodate; osmium(VIII) oxide / diethyl ether; water; tert-butyl alcohol / 40 h / 20 °C
With
1H-imidazole; sodium periodate; osmium(VIII) oxide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide;
In
diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
1: Baeyer-Villiger oxidation / 4: Claisen rearrangement / 6: Lemieux-Johnson oxidative cleavage;
DOI:10.1016/j.tet.2012.04.024
