N-cyclohexyl-N-methyl-4-<(5-methyl-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Base Information

Chemical Name:N-cyclohexyl-N-methyl-4-<(5-methyl-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide
CAS No.:105727-98-8
Molecular Formula:C₂₂H₃₀N₄O₃
Molecular Weight:398.505
Hs Code.:

Synonyms:N-cyclohexyl-N-methyl-4-<(5-methyl-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

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Chemical Property of N-cyclohexyl-N-methyl-4-<(5-methyl-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

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Technology Process of N-cyclohexyl-N-methyl-4-<(5-methyl-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

There total 5 articles about N-cyclohexyl-N-methyl-4-<(5-methyl-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109947-01-5
N-cyclohexyl-N-methyl-4-<3-(1-hydroxyethyl)-4-nitrophenoxy>butyramide

: 105727-98-8
N-cyclohexyl-N-methyl-4-<(5-methyl-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / TsCl, 4-(dimethylamino)pyridine / acetonitrile / Ambient temperature

2: 1.) NH₃, 2.) N,N-diisopropylethylamine, NaI / 1.) CHCl₃, 2.) EtOH, reflux, 48 h

3: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

4: 2.) conc. aq. NH₃ / 1.) EtOH, 24 h 2.) EtOH

With dmap; ammonium hydroxide; ammonia; hydrogen; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; sodium iodide; palladium on activated charcoal; In ethanol; acetonitrile;
DOI:10.1021/jm00385a012

Reference yield:

: 105728-56-1
N-cyclohexyl-N-methyl-4-<3-(1-chloroethyl)-4-nitrophenoxy>butyramide

: 105727-98-8
N-cyclohexyl-N-methyl-4-<(5-methyl-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NH₃, 2.) N,N-diisopropylethylamine, NaI / 1.) CHCl₃, 2.) EtOH, reflux, 48 h

2: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

3: 2.) conc. aq. NH₃ / 1.) EtOH, 24 h 2.) EtOH

With ammonium hydroxide; ammonia; hydrogen; N-ethyl-N,N-diisopropylamine; sodium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00385a012

Reference yield:

: 105728-57-2
(1-{5-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-phenyl}-ethylamino)-acetic acid ethyl ester

: 105727-98-8
N-cyclohexyl-N-methyl-4-<(5-methyl-1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

2: 2.) conc. aq. NH₃ / 1.) EtOH, 24 h 2.) EtOH

With ammonium hydroxide; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00385a012