benzoic acid 4-dimethylamino-2-(4-ethyl-11-methoxy-7,9,11,13,15-pentamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester

Base Information

Chemical Name:benzoic acid 4-dimethylamino-2-(4-ethyl-11-methoxy-7,9,11,13,15-pentamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester
CAS No.:484671-91-2
Molecular Formula:C₃₇H₅₄N₂O₁₁
Molecular Weight:702.843
Hs Code.:

benzoic acid 4-dimethylamino-2-(4-ethyl-11-methoxy-7,9,11,13,15-pentamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester

Synonyms:benzoic acid 4-dimethylamino-2-(4-ethyl-11-methoxy-7,9,11,13,15-pentamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester

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Chemical Property of benzoic acid 4-dimethylamino-2-(4-ethyl-11-methoxy-7,9,11,13,15-pentamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester

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Technology Process of benzoic acid 4-dimethylamino-2-(4-ethyl-11-methoxy-7,9,11,13,15-pentamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester

There total 12 articles about benzoic acid 4-dimethylamino-2-(4-ethyl-11-methoxy-7,9,11,13,15-pentamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 910249-79-5
benzoic acid 4-dimethylamino-2-(4-ethyl-8-hydroxy-11-methoxy-7,9,11,13,15-pentamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester

: 484671-91-2
benzoic acid 4-dimethylamino-2-(4-ethyl-11-methoxy-7,9,11,13,15-pentamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: benzoic acid 4-dimethylamino-2-(4-ethyl-8-hydroxy-11-methoxy-7,9,11,13,15-pentamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester; With N-chloro-succinimide; dimethylsulfide; In dichloromethane; at -20 ℃; for 0.666667h;

With triethylamine; In dichloromethane; at -20 - 0 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2006.05.104

Reference yield:

: 484671-90-1
Imidazole-1-carboxylic acid (E)-(2R,3S,7R,9R,10R,11R,13R)-10-((2S,3R,4S,6R)-3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-9-methoxy-5,7,9,11,13-pentamethyl-6,12,14-trioxo-oxacyclotetradec-4-en-3-yl ester

: 484671-91-2
benzoic acid 4-dimethylamino-2-(4-ethyl-11-methoxy-7,9,11,13,15-pentamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: With ammonia; In water; acetonitrile; at 70 ℃; for 23h;

Reference yield:

: 484672-56-2
C₅₁H₇₃NO₁₄

: 484671-91-2
benzoic acid 4-dimethylamino-2-(4-ethyl-11-methoxy-7,9,11,13,15-pentamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / -15 - 0 °C

2.1: aq. NH₃ / tetrahydrofuran; acetonitrile / 22 h / 50 °C

3.1: 92 percent / aq. HCl / acetonitrile / 26 h / 25 °C

4.1: N-chlorosuccinimide; Me₂S / CH₂Cl₂ / 0.67 h / -20 °C

4.2: 75 percent / Et₃N / CH₂Cl₂ / 0.5 h / -20 - 0 °C

With hydrogenchloride; ammonium hydroxide; N-chloro-succinimide; dimethylsulfide; sodium hydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2006.05.104