4-(4-chlorobenzyl)piperidine-4-carbonitrile hydrochloride

Base Information

• Chemical Name: 4-(4-chlorobenzyl)piperidine-4-carbonitrile hydrochloride
• CAS No.: 885500-41-4
• Molecular Formula: C₁₃H₁₅ClN₂*ClH
• Molecular Weight: 271.189
• Mol file: 885500-41-4.mol

Synonyms:4-(4-chlorobenzyl)piperidine-4-carbonitrile hydrochloride

Chemical Property of 4-(4-chlorobenzyl)piperidine-4-carbonitrile hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(4-chlorobenzyl)piperidine-4-carbonitrile hydrochloride

There total 2 articles about 4-(4-chlorobenzyl)piperidine-4-carbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-chlorobenzyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester (885500-39-0) → 4-(4-chlorobenzyl)piperidine-4-carbonitrile hydrochloride (885500-41-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 19h;

DOI:10.1021/jm701437d

Reference yield:

1-Chloro-4-(chloromethyl)benzene (104-83-6) → 4-(4-chlorobenzyl)piperidine-4-carbonitrile hydrochloride (885500-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; isopropylamine / tetrahydrofuran; hexanes / 1.17 h / -78 °C

1.2: 15 h / 20 °C

2.1: hydrogenchloride; methanol / 1,4-dioxane / 19 h

With hydrogenchloride; methanol; n-butyllithium; isopropylamine; In tetrahydrofuran; 1,4-dioxane; hexanes;

Reference yield:

4-(4-chlorobenzyl)piperidine-4-carbonitrile hydrochloride (885500-41-4) → C-[4-(4-chlorobenzyl)piperidin-4-yl]methylamine (885653-44-1)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1021/jm701437d

upstream raw materials:

4-(4-chlorobenzyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester

1-Chloro-4-(chloromethyl)benzene

Downstream raw materials:

C-[4-(4-chlorobenzyl)piperidin-4-yl]methylamine