4-(4-FLUOROPHENYL)-6-HYDROXY-2-PHENYL-5-PYRIMIDINECARBONITRILE

Base Information

• Chemical Name: 4-(4-FLUOROPHENYL)-6-HYDROXY-2-PHENYL-5-PYRIMIDINECARBONITRILE
• CAS No.: 477853-95-5
• Molecular Formula: C₁₇H₁₀FN₃O
• Molecular Weight: 291.284
• Hs Code.: 2933599590
• Mol file: 477853-95-5.mol

Synonyms:6-(p-fluorophenyl)-4-oxo-2-(phenyl)-3,4-dihydropyrimidine-5-carbonitrile

Chemical Property of 4-(4-FLUOROPHENYL)-6-HYDROXY-2-PHENYL-5-PYRIMIDINECARBONITRILE

Chemical Property:

• Melting Point: 330°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-Fluorophenyl)-6-hydroxy-2-phenylpyrimidine-5-carbonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-(4-FLUOROPHENYL)-6-HYDROXY-2-PHENYL-5-PYRIMIDINECARBONITRILE

There total 2 articles about 4-(4-FLUOROPHENYL)-6-HYDROXY-2-PHENYL-5-PYRIMIDINECARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzamidine monohydrochloride (1670-14-0) + ethyl 2-cyano-3-(4-fluorophenyl)acrylate (947739-65-3) → 6-(p-fluorophenyl)-4-oxo-2-(phenyl)-3,4-dihydropyrimidine-5-carbonitrile (477853-95-5)

Guidance literature:

With triethylamine; In methanol; at 20 ℃;

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 6-(p-fluorophenyl)-4-oxo-2-(phenyl)-3,4-dihydropyrimidine-5-carbonitrile (477853-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃ / ethanol / 20 °C

2: 95 percent / NEt₃ / methanol / 20 °C

With triethylamine; In methanol; ethanol; 1: Kuoevenagel condensation;

Reference yield: 38.0%

6-(p-fluorophenyl)-4-oxo-2-(phenyl)-3,4-dihydropyrimidine-5-carbonitrile (477853-95-5) + dimethyl sulfate (77-78-1) → 6-(p-fluorophenyl)-3-methyl-4-oxo-2-(phenyl)-3,4-dihydropyrimidine-5-carbonitrile

Guidance literature:

With sodium hydroxide; In water; at 60 ℃;

upstream raw materials:

benzamidine monohydrochloride

ethyl 2-cyano-3-(4-fluorophenyl)acrylate

4-fluorobenzaldehyde

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