N-[3-(1H-Indol-3-yl)-2-(trityl-amino)-propyl]-N-(3-methoxy-benzyl)-acetamide

Base Information

Chemical Name:N-[3-(1H-Indol-3-yl)-2-(trityl-amino)-propyl]-N-(3-methoxy-benzyl)-acetamide
CAS No.:1027854-74-5
Molecular Formula:C₄₀H₃₉N₃O₂
Molecular Weight:593.769
Hs Code.:

Synonyms:N-[3-(1H-Indol-3-yl)-2-(trityl-amino)-propyl]-N-(3-methoxy-benzyl)-acetamide

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Chemical Property of N-[3-(1H-Indol-3-yl)-2-(trityl-amino)-propyl]-N-(3-methoxy-benzyl)-acetamide

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Technology Process of N-[3-(1H-Indol-3-yl)-2-(trityl-amino)-propyl]-N-(3-methoxy-benzyl)-acetamide

There total 6 articles about N-[3-(1H-Indol-3-yl)-2-(trityl-amino)-propyl]-N-(3-methoxy-benzyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-24-7
acetic anhydride

: 1025872-10-9
3-(1H-Indol-3-yl)-N¹-(3-methoxy-benzyl)-N²-trityl-propane-1,2-diamine

: 1027854-74-5
N-[3-(1H-Indol-3-yl)-2-(trityl-amino)-propyl]-N-(3-methoxy-benzyl)-acetamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 4h;
DOI:10.1021/jm950616c

Reference yield:

: 76-83-5
trityl chloride

: 1027854-74-5
N-[3-(1H-Indol-3-yl)-2-(trityl-amino)-propyl]-N-(3-methoxy-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / triethylamine / CH₂Cl₂ / Ambient temperature

2: 48.68 g / borane methyl sulfide complex / tetrahydrofuran / 83 °C

3: toluene

4: sodium borohydride / tetrahydrofuran; methanol / 4 h

5: triethylamine / tetrahydrofuran / 4 h / 0 °C

With sodium tetrahydroborate; dimethylsulfide borane complex; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm950616c

Reference yield:

: 170568-17-9
(RS)-1-amino-3-(1H-indol-3-yl)-2-(N-(triphenylmethyl)amino)propane

: 1027854-74-5
N-[3-(1H-Indol-3-yl)-2-(trityl-amino)-propyl]-N-(3-methoxy-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene

2: sodium borohydride / tetrahydrofuran; methanol / 4 h

3: triethylamine / tetrahydrofuran / 4 h / 0 °C

With sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm950616c