3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperazine

Base Information

Chemical Name:3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperazine
CAS No.:241824-33-9
Molecular Formula:C₁₈H₃₂N₂O₃SSi
Molecular Weight:384.615
Hs Code.:

3-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperazine

Synonyms:3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperazine

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Chemical Property of 3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperazine

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Technology Process of 3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperazine

There total 4 articles about 3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 98-59-9
p-toluenesulfonyl chloride

: 241824-32-8
(R)-2-(tert-butyldimethylsiloxy)methylpiperazine

: 241824-33-9
3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperazine

Guidance literature:: With TEA; In chloroform;
DOI:10.1016/S0040-4039(99)01031-X

Reference yield:

: 149715-46-8
(R)-4-(phenylmethyl)-2-piperazinemethanol

: 241824-33-9
3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent

2: 100 percent / H₂ / Pd-C

3: 71 percent / TEA / CHCl₃

With TEA; hydrogen; palladium on activated charcoal; In chloroform; 1: Etherification / 2: deprotection / 3: Tosylation;
DOI:10.1016/S0040-4039(99)01031-X

Reference yield:

: 137442-19-4
(R)-4-Benzyl-piperazine-2-carboxylic acid

: 241824-33-9
3-(tert-butyl-dimethyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / LiAlH₄ / tetrahydrofuran

2: 93 percent

3: 100 percent / H₂ / Pd-C

4: 71 percent / TEA / CHCl₃

With lithium aluminium tetrahydride; TEA; hydrogen; palladium on activated charcoal; In tetrahydrofuran; chloroform; 1: Reduction / 2: Etherification / 3: deprotection / 4: Tosylation;
DOI:10.1016/S0040-4039(99)01031-X