(+)-(1S,3aS,4S,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxy-4-(2-(3-methoxyphenyl)ethyl)indane

Base Information

Chemical Name:(+)-(1S,3aS,4S,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxy-4-(2-(3-methoxyphenyl)ethyl)indane
CAS No.:220332-78-5
Molecular Formula:C₂₈H₄₄O₅Si
Molecular Weight:488.74
Hs Code.:

Synonyms:(+)-(1S,3aS,4S,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxy-4-(2-(3-methoxyphenyl)ethyl)indane

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Chemical Property of (+)-(1S,3aS,4S,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxy-4-(2-(3-methoxyphenyl)ethyl)indane

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Technology Process of (+)-(1S,3aS,4S,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxy-4-(2-(3-methoxyphenyl)ethyl)indane

There total 4 articles about (+)-(1S,3aS,4S,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxy-4-(2-(3-methoxyphenyl)ethyl)indane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5020-41-7
2-(3-methoxyphenyl)-ethanol

: 220332-78-5
(+)-(1S,3aS,4S,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxy-4-(2-(3-methoxyphenyl)ethyl)indane

Guidance literature:: Multi-step reaction with 2 steps

1: I₂, imidazole, Ph₃P / CH₂Cl₂

2: 1.) NaH, 2.) n-BuLi

With 1H-imidazole; n-butyllithium; iodine; sodium hydride; triphenylphosphine; In dichloromethane;
DOI:10.1021/ja983179a

Reference yield:

: 1798-09-0
m-methoxyphenylacetic acid

: 220332-78-5
(+)-(1S,3aS,4S,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxy-4-(2-(3-methoxyphenyl)ethyl)indane

Guidance literature:: Multi-step reaction with 3 steps

1: LAH / diethyl ether / Heating

2: I₂, imidazole, Ph₃P / CH₂Cl₂

3: 1.) NaH, 2.) n-BuLi

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; iodine; sodium hydride; triphenylphosphine; In diethyl ether; dichloromethane;
DOI:10.1021/ja983179a

Reference yield:

: 220332-76-3
(+)-(1S,3aS,7aS)-hexahydro-1-(tert-butyldimethylsiloxy)-7a-ethyl-5-indanone

: 220332-78-5
(+)-(1S,3aS,4S,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxy-4-(2-(3-methoxyphenyl)ethyl)indane

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NaH, MeOH / tetrahydrofuran; hexane / 1 h / Heating

2: 1.) NaH, 2.) n-BuLi

With methanol; n-butyllithium; sodium hydride; In tetrahydrofuran; hexane;
DOI:10.1021/ja983179a