[2-(4-{13,15-Dichloro-17-[4-(2-hydroxymethyl-phenyl)-butyl]-7,14,16,18-tetramethoxy-tricyclo[10.2.2.2^5,8]octadeca-1⁽¹⁵⁾,5⁽¹⁸⁾,6,8⁽¹⁷⁾,12⁽¹⁶⁾,13-hexaen-6-yl}-butyl)-phenyl]-methanol

Base Information

• Chemical Name: [2-(4-{13,15-Dichloro-17-[4-(2-hydroxymethyl-phenyl)-butyl]-7,14,16,18-tetramethoxy-tricyclo[10.2.2.2^5,8]octadeca-1⁽¹⁵⁾,5⁽¹⁸⁾,6,8⁽¹⁷⁾,12⁽¹⁶⁾,13-hexaen-6-yl}-butyl)-phenyl]-methanol
• CAS No.: 158586-78-8
• Molecular Formula: C₄₄H₅₄Cl₂O₆
• Molecular Weight: 749.815

Synonyms:[2-(4-{13,15-Dichloro-17-[4-(2-hydroxymethyl-phenyl)-butyl]-7,14,16,18-tetramethoxy-tricyclo[10.2.2.2^5,8]octadeca-1⁽¹⁵⁾,5⁽¹⁸⁾,6,8⁽¹⁷⁾,12⁽¹⁶⁾,13-hexaen-6-yl}-butyl)-phenyl]-methanol

Chemical Property of [2-(4-{13,15-Dichloro-17-[4-(2-hydroxymethyl-phenyl)-butyl]-7,14,16,18-tetramethoxy-tricyclo[10.2.2.2^5,8]octadeca-1⁽¹⁵⁾,5⁽¹⁸⁾,6,8⁽¹⁷⁾,12⁽¹⁶⁾,13-hexaen-6-yl}-butyl)-phenyl]-methanol

Chemical Property:

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Safty Information:

• Pictogram(s):  
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Technology Process of [2-(4-{13,15-Dichloro-17-[4-(2-hydroxymethyl-phenyl)-butyl]-7,14,16,18-tetramethoxy-tricyclo[10.2.2.2^5,8]octadeca-1⁽¹⁵⁾,5⁽¹⁸⁾,6,8⁽¹⁷⁾,12⁽¹⁶⁾,13-hexaen-6-yl}-butyl)-phenyl]-methanol

There total 9 articles about [2-(4-{13,15-Dichloro-17-[4-(2-hydroxymethyl-phenyl)-butyl]-7,14,16,18-tetramethoxy-tricyclo[10.2.2.2^5,8]octadeca-1⁽¹⁵⁾,5⁽¹⁸⁾,6,8⁽¹⁷⁾,12⁽¹⁶⁾,13-hexaen-6-yl}-butyl)-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-Bis(brommethyl)-2,5-bis(2-methoxycarbonylethyl)-3,6-dimethoxybenzol → [2-(4-{13,15-Dichloro-17-[4-(2-hydroxymethyl-phenyl)-butyl]-7,14,16,18-tetramethoxy-tricyclo[10.2.2.25,8]octadeca-1(15),5(18),6,8(17),12(16),13-hexaen-6-yl}-butyl)-phenyl]-methanol (158586-78-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 46 percent / KOH / methanol; tetrahydrofuran

2: 85 percent / MCPBA / CH₂Cl₂ / 90 h / 20 °C

3: 45 percent / gas / 535 °C / 1E-06 - 1E-05

4: 96 percent / LiAlH₄ / tetrahydrofuran / 20 °C

5: 70 percent / PCC, celite/MgSO₄ / CH₂Cl₂

6: 85 percent / CH₃ONa / tetrahydrofuran

7: 95 percent / H₂ / Pd/C / ethyl acetate; methanol / 1 h / 20 °C

8: LiAlH₄ / tetrahydrofuran / 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; Celite; hydrogen; sodium methylate; magnesium sulfate; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

Reference yield:

3-[13,15-Dichloro-7,14,16,18-tetramethoxy-17-(2-methoxycarbonyl-ethyl)-tricyclo[10.2.2.25,8]octadeca-1(15),5(18),6,8(17),12(16),13-hexaen-6-yl]-propionic acid methyl ester (158586-85-7,160474-05-5) → [2-(4-{13,15-Dichloro-17-[4-(2-hydroxymethyl-phenyl)-butyl]-7,14,16,18-tetramethoxy-tricyclo[10.2.2.25,8]octadeca-1(15),5(18),6,8(17),12(16),13-hexaen-6-yl}-butyl)-phenyl]-methanol (158586-78-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / LiAlH₄ / tetrahydrofuran / 20 °C

2: 70 percent / PCC, celite/MgSO₄ / CH₂Cl₂

3: 85 percent / CH₃ONa / tetrahydrofuran

4: 95 percent / H₂ / Pd/C / ethyl acetate; methanol / 1 h / 20 °C

5: LiAlH₄ / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; Celite; hydrogen; sodium methylate; magnesium sulfate; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

Reference yield:

3-[7,19-Dichloro-8,16,18,20-tetramethoxy-17-(2-methoxycarbonyl-ethyl)-3,12-dithia-tricyclo[12.2.2.26,9]icosa-1(17),6(20),7,9(19),14(18),15-hexaen-15-yl]-propionic acid methyl ester (158586-81-3,160474-03-3) → [2-(4-{13,15-Dichloro-17-[4-(2-hydroxymethyl-phenyl)-butyl]-7,14,16,18-tetramethoxy-tricyclo[10.2.2.25,8]octadeca-1(15),5(18),6,8(17),12(16),13-hexaen-6-yl}-butyl)-phenyl]-methanol (158586-78-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 85 percent / MCPBA / CH₂Cl₂ / 90 h / 20 °C

2: 45 percent / gas / 535 °C / 1E-06 - 1E-05

3: 96 percent / LiAlH₄ / tetrahydrofuran / 20 °C

4: 70 percent / PCC, celite/MgSO₄ / CH₂Cl₂

5: 85 percent / CH₃ONa / tetrahydrofuran

6: 95 percent / H₂ / Pd/C / ethyl acetate; methanol / 1 h / 20 °C

7: LiAlH₄ / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; Celite; hydrogen; sodium methylate; magnesium sulfate; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

upstream raw materials:

C₄₆H₅₄Cl₂O₈

3-[13,15-Dichloro-17-(3-hydroxy-propyl)-7,14,16,18-tetramethoxy-tricyclo[10.2.2.2^5,8]octadeca-1⁽¹⁵⁾,5⁽¹⁸⁾,6,8⁽¹⁷⁾,12⁽¹⁶⁾,13-hexaen-6-yl]-propan-1-ol

3-[13,15-Dichloro-7,14,16,18-tetramethoxy-17-(3-oxo-propyl)-tricyclo[10.2.2.2^5,8]octadeca-1⁽¹⁵⁾,5⁽¹⁸⁾,6,8⁽¹⁷⁾,12⁽¹⁶⁾,13-hexaen-6-yl]-propionaldehyde

3-[13,15-Dichloro-7,14,16,18-tetramethoxy-17-(2-methoxycarbonyl-ethyl)-tricyclo[10.2.2.2^5,8]octadeca-1⁽¹⁵⁾,5⁽¹⁸⁾,6,8⁽¹⁷⁾,12⁽¹⁶⁾,13-hexaen-6-yl]-propionic acid methyl ester

Downstream raw materials:

C₄₄H₅₀Cl₂O₆

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