Butanedioic acid, methyl-, 1-(phenylmethyl) ester, (2R)- (9CI)

Base Information

• Chemical Name: Butanedioic acid, methyl-, 1-(phenylmethyl) ester, (2R)- (9CI)
• CAS No.: 143225-28-9
• Molecular Formula: C12H14 O4
• Molecular Weight: 222.23716
• Mol file: 143225-28-9.mol

Synonyms:Butanedioicacid, methyl-, 1-(phenylmethyl) ester, (R)-;

Chemical Property of Butanedioic acid, methyl-, 1-(phenylmethyl) ester, (2R)- (9CI)

Chemical Property:

• PSA: 63.60000
• Density: 1.189
• LogP: 1.84060

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanedioic acid, methyl-, 1-(phenylmethyl) ester, (2R)- (9CI)

There total 3 articles about Butanedioic acid, methyl-, 1-(phenylmethyl) ester, (2R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(R)-2-Methyl-4-pentenoic acid phenylmethyl ester (147649-95-4,147649-96-5,144681-88-9) → benzyl (R)-2-methyl-4-pentenoate (143225-28-9)

Guidance literature:

(R)-2-Methyl-4-pentenoic acid phenylmethyl ester; With Oxone; In dichloromethane; at -78 ℃; Inert atmosphere;

With dihydrogen peroxide; In dichloromethane; Inert atmosphere;

DOI:10.1002/anie.201410371

Reference yield:

(2R,4R,5S)-4-methyl-3-(2-methyl-pent-4-enoyl)-5-phenyloxazolidin-2-one → benzyl (R)-2-methyl-4-pentenoate (143225-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / benzyl alcohol; pentane / 5 h / 0 - 20 °C / Inert atmosphere

2.1: Oxone / dichloromethane / -78 °C / Inert atmosphere

2.2: Inert atmosphere

With Oxone; sodium hydride; In dichloromethane; benzyl alcohol; pentane;

DOI:10.1002/anie.201410371

Reference yield:

→ benzyl (R)-2-methyl-4-pentenoate (143225-28-9)

Guidance literature:

upstream raw materials:

(R)-2-Methyl-4-pentenoic acid phenylmethyl ester