4-bromo-1-(bromomethyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

Base Information

• Chemical Name: 4-bromo-1-(bromomethyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile
• CAS No.: 143210-04-2
• Molecular Formula: C₁₃H₆Br₂ClF₃N₂
• Molecular Weight: 442.46
• Mol file: 143210-04-2.mol

Synonyms:4-bromo-1-(bromomethyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

Chemical Property of 4-bromo-1-(bromomethyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-1-(bromomethyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

There total 2 articles about 4-bromo-1-(bromomethyl)-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-((3-bromo-5-(4-chlorophenyl)-4-cyano-2-(trifluoromethyl)-1H-pyrrol-1-yl) methyl) acetamide (144032-68-8) → 4-Bromo-1-(bromomethyl)-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile (143210-04-2)

Guidance literature:

With phosphorus(V) oxybromide; for 0.5h; Reflux;

DOI:10.1021/jf802464d DOI:10.1021/jf801311h

Reference yield:

2-(p-chlorophenyl)-5-(trifluoromethyl)-pyrrole-3-carbonitrile (122454-23-3) → 4-Bromo-1-(bromomethyl)-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile (143210-04-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: bromine / chloroform / 4.5 h / 30 °C

2.1: sodium hydride / tetrahydrofuran / 0.58 h / 10 °C

2.2: 4 h / 50 - 70 °C

3.1: phosphorus(V) oxybromide / acetonitrile / 1 h / 80 °C

With bromine; sodium hydride; phosphorus(V) oxybromide; In tetrahydrofuran; chloroform; acetonitrile;

DOI:10.7717/peerj.12209

upstream raw materials:

N-((3-bromo-5-(4-chlorophenyl)-4-cyano-2-(trifluoromethyl)-1H-pyrrol-1-yl) methyl) acetamide

2-(p-chlorophenyl)-5-(trifluoromethyl)-pyrrole-3-carbonitrile