ethyl 7-<(1R,2S,3R*)-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate

Base Information

Chemical Name:ethyl 7-<(1R*,2S*,3R*)-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate
CAS No.:81424-24-0
Molecular Formula:C₂₃H₃₀O₅
Molecular Weight:386.488
Hs Code.:

Synonyms:ethyl 7-<(1R*,2S*,3R*)-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 7-<(1R*,2S*,3R*)-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate

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Technology Process of ethyl 7-<(1R*,2S*,3R*)-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate

There total 3 articles about ethyl 7-<(1R*,2S*,3R*)-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 81424-23-9,81446-10-8
ethyl 7-<(1R*S*,2S*,3R*)-1-carbomethoxy-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate

: 81424-24-0
ethyl 7-<(1R*,2S*,3R*)-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate

Guidance literature:: With sodium cyanide; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 75 - 80 ℃; for 6h;
DOI:10.1021/jo00134a011

Reference yield:

: 81424-59-1
7-iodo-5-heptynoic acid ethyl ester

: 81424-24-0
ethyl 7-<(1R*,2S*,3R*)-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate

Guidance literature:: Multi-step reaction with 2 steps

1: KH / 16 h

2: 99 percent / sodium cyanide / hexamethylphosphoric acid triamide / 6 h / 75 - 80 °C

With sodium cyanide; potassium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jo00134a011

Reference yield:

: 81424-22-8
methyl (1R*,2S*,3R*)-2-(dimethoxymethyl)-3-phenyl-5-oxocyclopentanecarboxylate

: 81424-24-0
ethyl 7-<(1R*,2S*,3R*)-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate

Guidance literature:: Multi-step reaction with 2 steps

1: KH / 16 h

2: 99 percent / sodium cyanide / hexamethylphosphoric acid triamide / 6 h / 75 - 80 °C

With sodium cyanide; potassium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jo00134a011