Technology Process of RF-Lys(OEG-Cbz)-O-octyl
There total 9 articles about RF-Lys(OEG-Cbz)-O-octyl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-oxo-1-phenyl-2,7,10,13-tetraoxa-4-azahexadecan-16-oic acid;
With
4-methyl-morpholine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
RF-Lys-O-octyl;
In
dichloromethane; N,N-dimethyl-formamide;
at 40 ℃;
for 15h;
Inert atmosphere;
DOI:10.1002/ejoc.201100648
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 20 °C
2.1: water; trifluoroacetic acid / 15 h / 20 °C
3.1: 4-methyl-morpholine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol / dichloromethane / 1 h / 20 °C / Inert atmosphere
3.2: 15 h / 40 °C / Inert atmosphere
With
4-methyl-morpholine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); water; sodium hydrogencarbonate; benzotriazol-1-ol; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201100648
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h
2.1: 4-methyl-morpholine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); benzotriazol-1-ol / dichloromethane / 1 h / 20 °C / Inert atmosphere
2.2: 15 h / 40 °C / Inert atmosphere
With
4-methyl-morpholine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol;
In
ethanol; dichloromethane;
DOI:10.1002/ejoc.201100648
