3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-benzoic acid ethyl ester

Base Information

• Chemical Name: 3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-benzoic acid ethyl ester
• CAS No.: 692205-79-1
• Molecular Formula: C₆₄H₇₂Br₂O₁₀
• Molecular Weight: 1161.08
• Mol file: 692205-79-1.mol

Synonyms:3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-benzoic acid ethyl ester

Chemical Property of 3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-benzoic acid ethyl ester

There total 15 articles about 3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1-(4-Bromo-benzyloxy)-3-bromomethyl-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzene (692204-62-9) + 3-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-5-hydroxymethyl-benzoic acid ethyl ester (692205-74-6) → 3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-benzoic acid ethyl ester (692205-79-1)

Guidance literature:

With 18-crown-6 ether; sodium hydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo049878p

Reference yield:

Iododecane (2050-77-3) → 3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-benzoic acid ethyl ester (692205-79-1)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate; 18-crown-6 / acetone / 12 h / Heating

2: 63 percent / sodium hydride; 18-crown-6 / tetrahydrofuran / 20 °C

3: 81 percent / borane-dimethyl sulfide complex / tetrahydrofuran / 8 h / Heating

4: 96 percent / triphenylphosphine; N-bromosuccinimide / tetrahydrofuran / 20 °C

5: 86 percent / potassium carbonate; 18-crown-6 / acetone / 12 h / Heating

6: 54 percent / sodium hydride; 18-crown-6 / tetrahydrofuran / 20 °C

With N-Bromosuccinimide; 18-crown-6 ether; dimethylsulfide borane complex; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; acetone;

DOI:10.1021/jo049878p

Reference yield:

ethyl 3,5-dihydroxybenzoate (4142-98-7) → 3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-benzoic acid ethyl ester (692205-79-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 26 percent / potassium carbonate; 18-crown-6 / acetone / 12 h / Heating

2: potassium carbonate; 18-crown-6 / tetrahydrofuran / 8 h / Heating

3: 1.67 g / sodium hydride / tetrahydrofuran / 1 h / 20 °C

4: 96 percent / borane-dimethyl sulfide complex / tetrahydrofuran / 8 h / Heating

5: 77 percent / triphenylphosphine; N-bromosuccinimide / tetrahydrofuran / 20 °C

6: 54 percent / sodium hydride; 18-crown-6 / tetrahydrofuran / 20 °C

With N-Bromosuccinimide; 18-crown-6 ether; dimethylsulfide borane complex; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; acetone;

DOI:10.1021/jo049878p

upstream raw materials:

1-(4-Bromo-benzyloxy)-3-bromomethyl-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzene

3-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-5-hydroxymethyl-benzoic acid ethyl ester

Iododecane

ethyl 3,5-dihydroxybenzoate

Downstream raw materials:

(3-{3-(4-bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-phenyl)-methanol