2-(2-N-BOC-AMINOETHYL) PYRIDINE

Base Information

• Chemical Name: 2-(2-N-BOC-AMINOETHYL) PYRIDINE
• CAS No.: 143185-43-7
• Molecular Formula: C12H18 N2 O2
• Molecular Weight: 222.287
• Hs Code.: 2933399090
• Mol file: 143185-43-7.mol

Synonyms:Carbamicacid, [2-(2-pyridinyl)ethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property of 2-(2-N-BOC-AMINOETHYL) PYRIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.505
• Boiling Point: 346.7°Cat760mmHg
• Flash Point: 163.5°C
• PSA: 51.22000
• Density: 1.056g/cm³
• LogP: 2.53970

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl 2-pyridin-2-ylethylcarbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-N-BOC-AMINOETHYL) PYRIDINE

There total 6 articles about 2-(2-N-BOC-AMINOETHYL) PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(aminoethyl)pyridine (2706-56-1) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (2-(pyridin-2-yl)ethyl)carbamate (143185-43-7)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 3.5h;

Reference yield: 69.0%

2-bromo-pyridine (109-04-6) + t-butyl N-vinylcarbamate (7150-72-3) → tert-butyl (2-(pyridin-2-yl)ethyl)carbamate (143185-43-7)

Guidance literature:

With Cyclohexanethiol; 10-phenyl-10H-phenothiazine; sodium formate; In water; dimethyl sulfoxide; at 23 ℃; for 16h; regioselective reaction; Irradiation; Inert atmosphere; Sealed tube; Cooling;

DOI:10.1021/jacs.9b01077

Reference yield: 33.0%

2-Ethylpyridine (100-71-0) + N-(tert-butyloxycarbonyl) azide (1070-19-5) → tert-butyl (2-(pyridin-2-yl)ethyl)carbamate (143185-43-7)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) triflimide; valeric acid; In 1,2-dichloro-ethane; at 100 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02738

upstream raw materials:

2-(aminoethyl)pyridine

di-tert-butyl dicarbonate

2-Ethylpyridine

N-(tert-butyloxycarbonyl) azide

Downstream raw materials:

N-[2-[6-(4-Oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]ethyl]benzamide

tert-butyl N-[2-(piperidin-2-yl)ethyl]carbamate

2-(2-tert-butoxycarbonylaminoethyl)-1-(3,4-dichlorobenzyl)pyridium bromide

(S)-3-Methyl-2-[3-methyl-3-(2-pyridin-2-yl-ethyl)-ureido]-butyric acid 4-nitro-phenyl ester

Refernces

• 1、 Zhang, Tao,Hu, Xuejiao,Dong, Xunqing,Li, Guigen,Lu, Hongjian. "Iridium-Catalyzed Unreactive C(sp3)-H Amination with 2,2,2-Trichloroethoxycarbonyl Azide". supporting information. p. 6260 - 6264. Retrieved 2018/10/02.
• 2、 -. "1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF". Page 163. . Retrieved 2008/06/13.