4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione

Base Information

• Chemical Name: 4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione
• CAS No.: 637358-02-2
• Molecular Formula: C₁₀H₈FN₃OS₂
• Molecular Weight: 269.323
• Mol file: 637358-02-2.mol

Synonyms:4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione

Chemical Property of 4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione

There total 1 articles about 4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-fluorophenyl isothiocyanate (1544-68-9) + cyanoacetic acid amide (107-91-5) → 4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione (637358-02-2)

Guidance literature:

With sulfur; triethylamine; In ethanol; for 1h; Heating;

DOI:10.1002/ardp.200300734

Reference yield: 85.0%

orthoformic acid triethyl ester (122-51-0) + 4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione (637358-02-2) → 3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one (637358-03-3)

Guidance literature:

With acetic anhydride; for 1h; Heating;

DOI:10.1002/ardp.200300734

Reference yield:

4-amino-5-carbamoyl-3-(4-fluorophenyl)thiazole-2(3H)thione (637358-02-2) → 7-(4-fluoro-benzylamino)-3-(4-fluoro-phenyl)-5-methyl-3H-thiazolo[4,5-d]pyrimidine-2-thione

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / 3 h / Heating

2: 78 percent / POCl₃ / 1 h / Heating

3: 72 percent / ethanol / 3 h / Heating

With trichlorophosphate; In ethanol;

DOI:10.1002/ardp.200300734

upstream raw materials:

4-fluorophenyl isothiocyanate

cyanoacetic acid amide

Downstream raw materials:

3-(4-fluoro-phenyl)-5-methyl-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one

3-(4-fluoro-phenyl)-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one

3-(4-fluoro-phenyl)-7-mercapto-3H-thiazolo[4,5-d]pyrimidine-2-thione

7-chloro-3-(4-fluoro-phenyl)-5-methyl-3H-thiazolo[4,5-d]pyrimidine-2-thione