1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine

Base Information

Chemical Name:1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine
CAS No.:861230-82-2
Molecular Formula:C₂₉H₃₃F₃N₂O₁₄S₃
Molecular Weight:786.779
Hs Code.:

1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine

Synonyms:1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine

Suppliers and Price of 1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine

There total 7 articles about 1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 861230-81-1
1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine

: 358-23-6
trifluoromethylsulfonic anhydride

: 861230-82-2
1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1002/ejoc.200500023

Reference yield:

: 861230-80-0
1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-α-L-threo-pentofuranosyl]-3-(benzyloxymethyl)thymine

: 861230-82-2
1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine

Guidance literature:: Multi-step reaction with 2 steps

1.1: DMAP; pyridine; trifluoromethanesulfonic anhydride / CH₂Cl₂ / 4 h / 0 °C

1.2: 72 percent / aq. NaHCO₃ / CH₂Cl₂ / 0 - 20 °C

2.1: 70 percent / DMAP; pyridine / CH₂Cl₂ / 4 h / 0 °C

With pyridine; dmap; trifluoromethanesulfonic acid anhydride; In dichloromethane;
DOI:10.1002/ejoc.200500023

Reference yield:

: 861230-79-7
1-[2-O-acetyl-3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-α-L-threo-pentofuranosyl]-3-(benzyloxymethyl)thymine

: 861230-82-2
1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsolfonyloxymethyl)-2-O-(trifluoromethylsulfonyl)-α-L-erythro-pentofuranosyl]-3-(benzyloxymethyl)thymine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / NH₃ / methanol / 0.25 h / 0 - 20 °C

2.1: DMAP; pyridine; trifluoromethanesulfonic anhydride / CH₂Cl₂ / 4 h / 0 °C

2.2: 72 percent / aq. NaHCO₃ / CH₂Cl₂ / 0 - 20 °C

3.1: 70 percent / DMAP; pyridine / CH₂Cl₂ / 4 h / 0 °C

With pyridine; dmap; ammonia; trifluoromethanesulfonic acid anhydride; In methanol; dichloromethane;
DOI:10.1002/ejoc.200500023