ethyl 3-(5-amino-2-hydroxyphenyl)propionate

Base Information

• Chemical Name: ethyl 3-(5-amino-2-hydroxyphenyl)propionate
• CAS No.: 146767-12-6
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.245
• Mol file: 146767-12-6.mol

Synonyms:ethyl 3-(5-amino-2-hydroxyphenyl)propionate

Chemical Property of ethyl 3-(5-amino-2-hydroxyphenyl)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(5-amino-2-hydroxyphenyl)propionate

There total 5 articles about ethyl 3-(5-amino-2-hydroxyphenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-ethyl 3-(2-hydroxy-5-nitrophenyl)acrylate (153136-77-7) → ethyl 3-(5-amino-2-hydroxyphenyl)propionate (146767-12-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 25 ℃; for 2h; under 760 Torr;

DOI:10.1016/S0968-0896(97)00090-4

Reference yield: 66.0%

ethyl 3-(2-hydroxy-5-nitrophenyl)propanoate (20921-11-3) → ethyl 3-(5-amino-2-hydroxyphenyl)propionate (146767-12-6)

Guidance literature:

With palladium 10% on activated carbon; lithium formate; In tetrahydrofuran; for 1h; Reflux;

DOI:10.1016/j.bmc.2014.08.004

Reference yield:

C6H4(CH2CH2C(O)O) (119-84-6,1341-36-2) → ethyl 3-(5-amino-2-hydroxyphenyl)propionate (146767-12-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic anhydride; nitric acid; acetic acid / 1 h / 18 - 20 °C

2: 1 h / Reflux

3: lithium formate; palladium 10% on activated carbon / tetrahydrofuran / 1 h / Reflux

With palladium 10% on activated carbon; lithium formate; nitric acid; acetic anhydride; acetic acid; In tetrahydrofuran;

DOI:10.1016/j.bmc.2014.08.004

upstream raw materials:

(E)-ethyl 3-(2-hydroxy-5-nitrophenyl)acrylate

C₆H₄(CH₂CH₂C(O)O)

6-nitro-3,4-dihydrocoumarin

ethyl 3-(2-hydroxy-5-nitrophenyl)propanoate

Downstream raw materials:

ethyl-3-{5-[4-(dimethylaminocarbonyl)butanoylamino]-2-hydroxyphenyl}propanoate

ethyl 3-(2-acetoxy-5-acetylamino-4-nitrophenyl)propionate

ethyl-3-(2-acetoxy-5-acetylamino-4-aminophenyl)propionate

ethyl 3-(2-acetoxy-5-acetylaminophenyl)propionate