[2-(2-amino-3-methylbutyrylamino)-3-hydroxy-3-methylpentanoylamino]acetic acid benzyl ester

Base Information

Chemical Name:[2-(2-amino-3-methylbutyrylamino)-3-hydroxy-3-methylpentanoylamino]acetic acid benzyl ester
CAS No.:912341-68-5
Molecular Formula:C₂₀H₃₁N₃O₅
Molecular Weight:393.483
Hs Code.:

Synonyms:[2-(2-amino-3-methylbutyrylamino)-3-hydroxy-3-methylpentanoylamino]acetic acid benzyl ester

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Chemical Property of [2-(2-amino-3-methylbutyrylamino)-3-hydroxy-3-methylpentanoylamino]acetic acid benzyl ester

Chemical Property:

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Technology Process of [2-(2-amino-3-methylbutyrylamino)-3-hydroxy-3-methylpentanoylamino]acetic acid benzyl ester

There total 6 articles about [2-(2-amino-3-methylbutyrylamino)-3-hydroxy-3-methylpentanoylamino]acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 912341-87-8
[2-(2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-hydroxy-3-methylpentanoylamino]acetic acid benzyl ester

: 912341-68-5
[2-(2-amino-3-methylbutyrylamino)-3-hydroxy-3-methylpentanoylamino]acetic acid benzyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2006.06.071

Reference yield:

: ((1S,2R)-1-Formyl-2-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester

: 912341-68-5
[2-(2-amino-3-methylbutyrylamino)-3-hydroxy-3-methylpentanoylamino]acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 0.74 g / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 4 h

2: 98 percent / NaHCO₃; EDCI*HCl; HOBt / dimethylformamide / 0 - 20 °C

3: 94 percent / TFA / CH₂Cl₂ / 5 h / 0 - 20 °C

4: 89 percent / EDCI*HCl; HOBt / dimethylformamide / 0 - 20 °C

5: 100 percent / TFA / CH₂Cl₂ / 3 h / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2006.06.071

Reference yield:

: 912341-86-7
(2-amino-3-hydroxy-3-methylpentanoylamino)acetic acid benzyl ester

: 912341-68-5
[2-(2-amino-3-methylbutyrylamino)-3-hydroxy-3-methylpentanoylamino]acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / EDCI*HCl; HOBt / dimethylformamide / 0 - 20 °C

2: 100 percent / TFA / CH₂Cl₂ / 3 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.06.071