Technology Process of 8,9-dimethoxy-1-(4-methylbenzyl)-2,6-dihydropyrido[2,1-a]isoindol-4(3H)-one
There total 7 articles about 8,9-dimethoxy-1-(4-methylbenzyl)-2,6-dihydropyrido[2,1-a]isoindol-4(3H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; triphenylphosphine;
In
N,N-dimethyl-formamide;
at 120 ℃;
for 72h;
Inert atmosphere;
DOI:10.1016/j.tet.2011.12.060
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetonitrile / 4 h / 5 - 80 °C / Molecular sieve
1.2: 2 h / 23 - 80 °C
2.1: acetic acid / 1,2-dichloro-ethane / 12 h / Reflux
3.1: palladium diacetate; caesium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 72 h / 120 °C / Inert atmosphere
With
palladium diacetate; caesium carbonate; acetic acid; triphenylphosphine;
In
1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
1.1: Michael addition / 3.1: Heck reaction;
DOI:10.1016/j.tet.2011.12.060
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert-butyldimethylsilane; methyl carbamate; trifluoroacetic acid / acetonitrile / 6 h / 80 °C
1.2: 16 h / 80 °C
2.1: acetic acid / 1,2-dichloro-ethane / 12 h / Reflux
3.1: palladium diacetate; caesium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 72 h / 120 °C / Inert atmosphere
With
tert-butyldimethylsilane; palladium diacetate; caesium carbonate; acetic acid; triphenylphosphine; methyl carbamate; trifluoroacetic acid;
In
1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
3.1: Heck reaction;
DOI:10.1016/j.tet.2011.12.060