N-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)-2,2-diphenylacetamide

Base Information

Chemical Name:N-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)-2,2-diphenylacetamide
CAS No.:1343459-77-7
Molecular Formula:C₂₃H₁₈N₄O₂
Molecular Weight:382.422
Hs Code.:

Synonyms:N-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)-2,2-diphenylacetamide

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Chemical Property of N-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)-2,2-diphenylacetamide

Chemical Property:

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Technology Process of N-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)-2,2-diphenylacetamide

There total 5 articles about N-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)-2,2-diphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117-34-0
2,2-diphenylacetic acid

: 1343461-00-6
5-amino-2-(pyridin-2-yl)pyrimidin-4-ol

: 1343459-77-7
N-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)-2,2-diphenylacetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 100-70-9,1232006-36-8
2-Cyanopyridine

: 1343459-77-7
N-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)-2,2-diphenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 24 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C

2.1: sodium methylate / methanol / Reflux

2.2: 2 h / Reflux

2.3: 2 h / 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / toluene / Reflux

4.1: hydrogen / palladium on activated charcoal / methanol / 760.05 Torr

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 1 h / 20 °C

With diphenyl phosphoryl azide; hydrogen; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; toluene; acetonitrile; 3.1: Curtius Rearrangement;

Reference yield:

: 51285-26-8,61097-49-2
pyridine-2-carboxamidine hydrochloride

: 1343459-77-7
N-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)-2,2-diphenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / Reflux

1.2: 2 h / Reflux

1.3: 2 h / 20 °C

2.1: triethylamine; diphenyl phosphoryl azide / toluene / Reflux

3.1: hydrogen / palladium on activated charcoal / methanol / 760.05 Torr

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 1 h / 20 °C

With diphenyl phosphoryl azide; hydrogen; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; toluene; acetonitrile; 2.1: Curtius Rearrangement;