4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester

Base Information

• Chemical Name: 4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester
• CAS No.: 187157-31-9
• Molecular Formula: C₆₅H₆₂ClNO₁₅
• Molecular Weight: 1132.66
• Mol file: 187157-31-9.mol

Synonyms:4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester

Chemical Property of 4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester

There total 1 articles about 4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-Methyl-benzoic acid (2R,3R,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-hydroxy-tetrahydro-pyran-2-ylmethyl ester (162609-61-2) + Chloroacetic anhydride (541-88-8) → 4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester (187157-31-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/S0008-6215(96)90116-0

Reference yield: 87.0%

4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester (187157-31-9) → 4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-hydroxy-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester

Guidance literature:

With ammonium cerium(IV) nitrate; In water; toluene; acetonitrile; for 2h; Ambient temperature;

DOI:10.1016/S0008-6215(96)90116-0

Reference yield:

4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester (187157-31-9) → 4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-fluoro-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester (187157-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / CAN / toluene; acetonitrile; H₂O / 2 h / Ambient temperature

2: 648 mg / DAST / CH₂Cl₂ / 0.83 h / -15 - 0 °C

With ammonium cerium(IV) nitrate; 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; water; toluene; acetonitrile;

DOI:10.1016/S0008-6215(96)90116-0

upstream raw materials:

4-Methyl-benzoic acid (2R,3R,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yloxy]-4-hydroxy-tetrahydro-pyran-2-ylmethyl ester

Chloroacetic anhydride

Downstream raw materials:

4-Methyl-benzoic acid (2R,3S,4S,5R,6S)-3,5-bis-benzyloxy-6-[(2R,3S,4R,5R,6S)-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-fluoro-tetrahydro-pyran-3-yloxy]-4-(2-chloro-acetoxy)-tetrahydro-pyran-2-ylmethyl ester