N¹,N⁴-bis[(L)-N-tert-butoxycarbonylthreonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine

Base Information

• Chemical Name: N¹,N⁴-bis[(L)-N-tert-butoxycarbonylthreonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine
• CAS No.: 97106-79-1
• Molecular Formula: C₃₃H₅₅N₅O₁₁
• Molecular Weight: 697.827

Synonyms:N¹,N⁴-bis[(L)-N-tert-butoxycarbonylthreonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine

Chemical Property of N¹,N⁴-bis[(L)-N-tert-butoxycarbonylthreonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine

Chemical Property:

Purity/Quality:

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Technology Process of N¹,N⁴-bis[(L)-N-tert-butoxycarbonylthreonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine

There total 8 articles about N¹,N⁴-bis[(L)-N-tert-butoxycarbonylthreonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-tert-butoxycarbonyl-L-threonine N-hydroxysuccinimide ester (63076-44-8) + N1-(2,3-dimethoxybenzoyl)norspermidine (96857-09-9) → N1,N4-bis[(L)-N-tert-butoxycarbonylthreonyl]-N7-(2,3-dimethoxybenzoyl)norspermidine (97106-79-1)

Guidance literature:

In N,N-dimethyl-formamide; for 68h;

DOI:10.1016/S0040-4020(01)96492-0

Reference yield:

N1-(tert-butoxycarbonyl)-N8-(2,3-dimethoxybenzoyl)norspermidine (943136-36-5) → N1,N4-bis[(L)-N-tert-butoxycarbonylthreonyl]-N7-(2,3-dimethoxybenzoyl)norspermidine (97106-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane;

DOI:10.1055/s-2007-965960

Reference yield:

2,3-dimethoxybenzoic acid (1521-38-6) → N1,N4-bis[(L)-N-tert-butoxycarbonylthreonyl]-N7-(2,3-dimethoxybenzoyl)norspermidine (97106-79-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / 1,1'-carbonyldiimidazole / CH₂Cl₂ / 16 h / 0 - 20 °C

2: 97 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 - 20 °C

With 1,1'-carbonyldiimidazole; trifluoroacetic acid; In dichloromethane;

DOI:10.1055/s-2007-965960

upstream raw materials:

N-tert-butoxycarbonyl-L-threonine N-hydroxysuccinimide ester

N¹-(2,3-dimethoxybenzoyl)norspermidine

Boc-Thr-OH

N¹-(tert-butoxycarbonyl)-N⁸-(2,3-dimethoxybenzoyl)norspermidine

Downstream raw materials:

N-(3-{((2S,3R)-2-Amino-3-hydroxy-butyryl)-[3-((2S,3R)-2-amino-3-hydroxy-butyrylamino)-propyl]-amino}-propyl)-2,3-dimethoxy-benzamide; compound with trifluoro-acetic acid

N¹,N⁴-bis[(L)-threonyl]-N⁷-(2,3-dimethoxybenzoyl)norspermidine dihydrobromide

N-[3-(2,3-dihydroxybenzamido)propyl]-1,3-bis[2-(2,3-dihydroxyphenyl)-trans-5-methyl-2-oxazoline-4-carboxamido]propane

N-[3-(2,3-dihydroxybenzamido)propyl]-1,3-bis[2-(2-hydroxyphenyl)-trans-5-methyl-2-oxazoline-4-carboxamido]propane

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