1-(6-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-3-(4-methylpyridin-2-yl)propane-1,3-dione

Base Information

Chemical Name:1-(6-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-3-(4-methylpyridin-2-yl)propane-1,3-dione
CAS No.:317333-19-0
Molecular Formula:C₂₄H₂₀N₂O₄
Molecular Weight:400.434
Hs Code.:

Synonyms:1-(6-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-3-(4-methylpyridin-2-yl)propane-1,3-dione

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Chemical Property of 1-(6-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-3-(4-methylpyridin-2-yl)propane-1,3-dione

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Technology Process of 1-(6-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-3-(4-methylpyridin-2-yl)propane-1,3-dione

There total 8 articles about 1-(6-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-3-(4-methylpyridin-2-yl)propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13509-13-2
4-methylpyridine-2-carboxylic acid methyl ester

: 317334-92-2
8-acetyl-6-benzyl-4H-benzo[1,4]oxazin-3-one

: 317333-19-0
1-(6-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-3-(4-methylpyridin-2-yl)propane-1,3-dione

Guidance literature:: With sodium ethanolate; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 317334-90-0
3-benzyl-5-bromo-6-hydroxyaniline

: 317333-19-0
1-(6-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-3-(4-methylpyridin-2-yl)propane-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate / chloroform / 0 - 55 °C

2.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C

2.2: 1 h

3.1: sodium ethanolate / tetrahydrofuran / 4 h / 20 °C

With -butyl vinyl ether; N-benzyl-N,N,N-triethylammonium chloride; sodium ethanolate; sodium hydrogencarbonate; triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); chloroform;

Reference yield:

: 317334-91-1
6-benzyl-8-bromo-4H-benzo[1,4]oxazin-3-one

: 317333-19-0
1-(6-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-3-(4-methylpyridin-2-yl)propane-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C

1.2: 1 h

2.1: sodium ethanolate / tetrahydrofuran / 4 h / 20 °C

With -butyl vinyl ether; sodium ethanolate; triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);