4-({[3-({5-[(3-aminopropyl)amino]pentyl}oxy)-5-{[(4-carbamimidoylphenyl)amino]methyl}phenyl]methyl}amino)benzene-1-carboximidamide

Base Information

• Chemical Name: 4-({[3-({5-[(3-aminopropyl)amino]pentyl}oxy)-5-{[(4-carbamimidoylphenyl)amino]methyl}phenyl]methyl}amino)benzene-1-carboximidamide
• CAS No.: 1449308-36-4
• Molecular Formula: C₃₀H₄₂N₈O
• Molecular Weight: 530.716

Synonyms:4-({[3-({5-[(3-aminopropyl)amino]pentyl}oxy)-5-{[(4-carbamimidoylphenyl)amino]methyl}phenyl]methyl}amino)benzene-1-carboximidamide

Chemical Property of 4-({[3-({5-[(3-aminopropyl)amino]pentyl}oxy)-5-{[(4-carbamimidoylphenyl)amino]methyl}phenyl]methyl}amino)benzene-1-carboximidamide

Chemical Property:

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Technology Process of 4-({[3-({5-[(3-aminopropyl)amino]pentyl}oxy)-5-{[(4-carbamimidoylphenyl)amino]methyl}phenyl]methyl}amino)benzene-1-carboximidamide

There total 2 articles about 4-({[3-({5-[(3-aminopropyl)amino]pentyl}oxy)-5-{[(4-carbamimidoylphenyl)amino]methyl}phenyl]methyl}amino)benzene-1-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C40H58N8O5 → 4-({[3-({5-[(3-aminopropyl)amino]pentyl}oxy)-5-{[(4-carbamimidoylphenyl)amino]methyl}phenyl]methyl}amino)benzene-1-carboximidamide (1449308-36-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1002/chem.201300519

Reference yield:

(3-tert-butoxycarbonylaminopropyl)-(5-iodopentyl)-carbamic acid tert-butyl ester + C22H24N6O (1402737-03-4) → 4-({[3-({5-[(3-aminopropyl)amino]pentyl}oxy)-5-{[(4-carbamimidoylphenyl)amino]methyl}phenyl]methyl}amino)benzene-1-carboximidamide (1449308-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h

1.2: 2 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With potassium tert-butylate; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;

DOI:10.1002/chem.201300519

Reference yield:

4-({[3-({5-[(3-aminopropyl)amino]pentyl}oxy)-5-{[(4-carbamimidoylphenyl)amino]methyl}phenyl]methyl}amino)benzene-1-carboximidamide (1449308-36-4) + 5'-(ethoxycarbonyl)-2,2'-bipyridine-5-carboxylic acid (105501-69-7) → C44H52N10O4

Guidance literature:

5'-(ethoxycarbonyl)-2,2'-bipyridine-5-carboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

4-({[3-({5-[(3-aminopropyl)amino]pentyl}oxy)-5-{[(4-carbamimidoylphenyl)amino]methyl}phenyl]methyl}amino)benzene-1-carboximidamide; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1002/anie.201405726

upstream raw materials:

C₂₂H₂₄N₆O

Downstream raw materials:

C₃₂H₄₃BrN₈O₂

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