N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine tert-butyl ester

Base Information

Chemical Name:N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine tert-butyl ester
CAS No.:600173-00-0
Molecular Formula:C₃₃H₃₆N₃O₁₀P
Molecular Weight:665.637
Hs Code.:

Synonyms:N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine tert-butyl ester

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Technology Process of N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine tert-butyl ester

There total 4 articles about N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 600172-99-4
N-α-Fmoc-phosphi(1-nitrophenylethyl-2-cyanoethyl)-L-serine tert-butyl ester

: 600173-00-0
N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine tert-butyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo0344891

Reference yield:

: 111061-56-4,212688-51-2
Fmoc-Ser(Trt)-OH

: 600173-00-0
N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / CH₂Cl₂; tetrahydrofuran / 20 °C

2: 99 percent / trifluoroacetic acid; triisopropylsilane / CH₂Cl₂ / 1 h / 20 °C

3: 4,5-dicyanoimidazole / tetrahydrofuran / 20 °C

4: 1.27 g / m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h / 20 °C

With 4,5-dicyano-1H-imidazole; chlorotriisopropylsilane; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0344891

Reference yield:

: 110797-35-8
N-[(9-fluorenyl)methoxycarbonyl]-L-serine tert-butyl ester

: 600173-00-0
N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4,5-dicyanoimidazole / tetrahydrofuran / 20 °C

2: 1.27 g / m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h / 20 °C

With 4,5-dicyano-1H-imidazole; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0344891