(R)-2-[((R)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol

Base Information

• Chemical Name: (R)-2-[((R)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol
• CAS No.: 205526-51-8
• Molecular Formula: C₂₆H₃₇NO₆
• Molecular Weight: 459.583
• Mol file: 205526-51-8.mol

Synonyms:(R)-2-[((R)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol

Chemical Property of (R)-2-[((R)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[((R)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol

There total 5 articles about (R)-2-[((R)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3-(1,3-dioxolan-2-yl)propyl)magnesium bromide (91083-05-5) + (R)-2-Methyl-4-phenyl-3-(2,4,6-trimethoxy-benzyl)-oxazolidine → (R)-2-[((R)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol (205526-51-8)

Guidance literature:

In tetrahydrofuran; Mechanism; Ambient temperature;

DOI:10.1021/jo971127i

Reference yield: 96.4%

2-(3-bromopropyl)-1,3-dioxolane (62563-07-9) + (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2-methyl-4-phenyl-1,3-oxazolidine (205526-50-7) → (R)-2-[((R)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol (205526-51-8)

Guidance literature:

With magnesium; In tetrahydrofuran; at 0 ℃; for 72h;

DOI:10.3987/com-97-s32

Reference yield:

2,4,6-trimethoxybenzaldehyde (830-79-5) → (R)-2-[((R)-4-[1,3]Dioxolan-2-yl-1-methyl-butyl)-(2,4,6-trimethoxy-benzyl)-amino]-2-phenyl-ethanol (205526-51-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) sodium borohydride / 1.) benzene, reflux, 1 h; 2.) MeOH, r.t., 40 min

2: 100 percent / molecular sieve 3A / CH₂Cl₂ / 15 h / Ambient temperature

3: 96.4 percent / Mg / tetrahydrofuran / 72 h / 0 °C

With sodium tetrahydroborate; 3 A molecular sieve; magnesium; In tetrahydrofuran; dichloromethane;

DOI:10.3987/com-97-s32

upstream raw materials:

2-(3-bromopropyl)-1,3-dioxolane

(2R,4R)-N-(2,4,6-trimethoxybenzyl)-2-methyl-4-phenyl-1,3-oxazolidine

(3-(1,3-dioxolan-2-yl)propyl)magnesium bromide

2,4,6-trimethoxybenzaldehyde

Downstream raw materials:

(2R)-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methylpiperidine

(-)-(2'R)-((2R,6S)-2,6-dimethylpiperidin-1-yl)-2'-phenylethanol

(+)-(2R)-2-methylpiperidine hydrochloride

(3R,5R)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine