(E)-N-(6-chloro-4-methyl-4-hexenyl)-N-methyl-4-azidotetrafluoroaniline

Base Information

Chemical Name:(E)-N-(6-chloro-4-methyl-4-hexenyl)-N-methyl-4-azidotetrafluoroaniline
CAS No.:447454-36-6
Molecular Formula:C₁₄H₁₅ClF₄N₄
Molecular Weight:350.747
Hs Code.:

Synonyms:(E)-N-(6-chloro-4-methyl-4-hexenyl)-N-methyl-4-azidotetrafluoroaniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-(6-chloro-4-methyl-4-hexenyl)-N-methyl-4-azidotetrafluoroaniline

Chemical Property:

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Technology Process of (E)-N-(6-chloro-4-methyl-4-hexenyl)-N-methyl-4-azidotetrafluoroaniline

There total 7 articles about (E)-N-(6-chloro-4-methyl-4-hexenyl)-N-methyl-4-azidotetrafluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 447454-35-5
N-(6-(tert-butyldimethylsilyloxy)-4-methyl-4-hexenyl)-N-methyl-4-azidotetrafluoroaniline

: 447454-36-6
(E)-N-(6-chloro-4-methyl-4-hexenyl)-N-methyl-4-azidotetrafluoroaniline

Guidance literature:: With dichlorotriphenylphosphorane; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1021/ja0124717

Reference yield:

: 447454-31-1
E-1-(tert-butyldimethylsilyloxy)-3-methyl-hex-2-en-6-al

: 447454-36-6
(E)-N-(6-chloro-4-methyl-4-hexenyl)-N-methyl-4-azidotetrafluoroaniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; TiCl₄ / CH₂Cl₂; toluene / 0.08 h / -78 °C

1.2: CH₂Cl₂; toluene / 20 °C

1.3: 60 percent / NaBH(OAc)3; glacial acetic acid / CH₂Cl₂; toluene / 20 h / 20 °C

2.1: 87 percent / dichlorotriphenylphosphorane / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; titanium tetrachloride; dichlorotriphenylphosphorane; In dichloromethane; toluene;
DOI:10.1021/ja0124717

Reference yield:

: 294187-76-1
4-(N-(tert-butoxycarbonyl)amino)tetrafluorophenyl azide

: 447454-36-6
(E)-N-(6-chloro-4-methyl-4-hexenyl)-N-methyl-4-azidotetrafluoroaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 93 percent / tetrahydrofuran / 5 °C

2.1: HCl; AcOH / CH₂Cl₂ / 0 - 20 °C

3.1: pyridine; TiCl₄ / CH₂Cl₂; toluene / 0.08 h / -78 °C

3.2: CH₂Cl₂; toluene / 20 °C

3.3: 60 percent / NaBH(OAc)3; glacial acetic acid / CH₂Cl₂; toluene / 20 h / 20 °C

4.1: 87 percent / dichlorotriphenylphosphorane / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; hydrogenchloride; titanium tetrachloride; acetic acid; lithium hexamethyldisilazane; dichlorotriphenylphosphorane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja0124717