2-(4-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazole

Base Information

• Chemical Name: 2-(4-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazole
• CAS No.: 1469283-57-5
• Molecular Formula: C₂₇H₁₇F₃N₄O₂
• Molecular Weight: 486.453

Synonyms:2-(4-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazole

Chemical Property of 2-(4-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazole

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Technology Process of 2-(4-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazole

There total 3 articles about 2-(4-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-trifluoromethylphenylazide (22001-17-8) + 2-(4-(prop-2-yn-1-yloxy)phenyl)-naphtho[1,2-d]oxazole (1469283-54-2) → 2-(4-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazole (1469283-57-5)

Guidance literature:

With copper(l) iodide; In tetrahydrofuran; at 50 ℃; for 6h; Inert atmosphere;

DOI:10.1007/s00044-013-0784-0

Reference yield:

2-(2-hydroxynaphthalen-1-yl)(4-hydroxyphenyl) (205386-28-3) → 2-(4-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazole (1469283-57-5)

Guidance literature:

Multi-step reaction with 3 steps

1: acetylhydroxamic acid; sulfuric acid / acetonitrile / 0.17 h / 80 °C / 1292.9 Torr / Microwave irradiation

2: potassium carbonate / acetone / 4 h / Inert atmosphere; Reflux

3: copper(l) iodide / tetrahydrofuran / 6 h / 50 °C / Inert atmosphere

With copper(l) iodide; acetylhydroxamic acid; sulfuric acid; potassium carbonate; In tetrahydrofuran; acetone; acetonitrile; 3: |Huisgen Tetrazole Rearrangement;

DOI:10.1007/s00044-013-0784-0

Reference yield:

4-(naphtho[1,2-d]oxazol-2-yl)phenol (52469-57-5) → 2-(4-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazole (1469283-57-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 4 h / Inert atmosphere; Reflux

2: copper(l) iodide / tetrahydrofuran / 6 h / 50 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; In tetrahydrofuran; acetone; 2: |Huisgen Tetrazole Rearrangement;

DOI:10.1007/s00044-013-0784-0

upstream raw materials:

2-(2-hydroxynaphthalen-1-yl)(4-hydroxyphenyl)

3-trifluoromethylphenylazide

2-(4-(prop-2-yn-1-yloxy)phenyl)-naphtho[1,2-d]oxazole

4-(naphtho[1,2-d]oxazol-2-yl)phenol

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