N-(3-amino-2-fluoro-5-methyl-phenyl)-N'-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamide

Base Information

Chemical Name:N-(3-amino-2-fluoro-5-methyl-phenyl)-N'-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamide
CAS No.:925916-11-6
Molecular Formula:C₃₉H₅₁F₃N₄O₃
Molecular Weight:680.854
Hs Code.:

<i>N</i>-(3-amino-2-fluoro-5-methyl-phenyl)-<i>N</i>'-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamide

Synonyms:N-(3-amino-2-fluoro-5-methyl-phenyl)-N'-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamide

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Chemical Property of N-(3-amino-2-fluoro-5-methyl-phenyl)-N'-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamide

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Technology Process of N-(3-amino-2-fluoro-5-methyl-phenyl)-N'-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamide

There total 7 articles about N-(3-amino-2-fluoro-5-methyl-phenyl)-N'-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 925915-70-4
N-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamic acid

: 20372-69-4
2-fluoro-5-methylbenzene-1,3-diamine

: 925916-11-6
N-(3-amino-2-fluoro-5-methyl-phenyl)-N'-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1002/anie.200500982

Reference yield:

: 4-fluoro-2-methyl-5-nitrobenzoyl chloride

: 925916-11-6
N-(3-amino-2-fluoro-5-methyl-phenyl)-N'-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamide

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Et₃N / CH₂Cl₂

2: 95 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 24 h / 20 °C / 760 Torr

3: 91 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

4: 98 percent / LiOH; H₂O / tetrahydrofuran / 5 h / 20 °C

5: 45 percent / EDCI; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; lithium hydroxide; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/anie.200500982

Reference yield:

: 925915-38-4
4-fluoro-2-methyl-5-nitro-N,N-dioctyl-benzamide

: 925916-11-6
N-(3-amino-2-fluoro-5-methyl-phenyl)-N'-(5-dioctylcarbamoyl-2-fluoro-4-methyl-phenyl)-2-fluoro-isophthalamide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 24 h / 20 °C / 760 Torr

2: 91 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

3: 98 percent / LiOH; H₂O / tetrahydrofuran / 5 h / 20 °C

4: 45 percent / EDCI; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; lithium hydroxide; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/anie.200500982