(S)-2-(tert-butoxycarbonylamino-methyl)-3-(4-chlorophenyl)-propionic acid

Base Information

Chemical Name:(S)-2-(tert-butoxycarbonylamino-methyl)-3-(4-chlorophenyl)-propionic acid
CAS No.:853681-17-1
Molecular Formula:C₁₅H₂₀ClNO₄
Molecular Weight:313.781
Hs Code.:

Synonyms:(S)-2-(tert-butoxycarbonylamino-methyl)-3-(4-chlorophenyl)-propionic acid

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Chemical Property of (S)-2-(tert-butoxycarbonylamino-methyl)-3-(4-chlorophenyl)-propionic acid

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Technology Process of (S)-2-(tert-butoxycarbonylamino-methyl)-3-(4-chlorophenyl)-propionic acid

There total 5 articles about (S)-2-(tert-butoxycarbonylamino-methyl)-3-(4-chlorophenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: [(2S)-2-(4-chlorobenzyl)-3-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-carbamic acid tert-butyl ester

: 853681-17-1
(S)-2-(tert-butoxycarbonylamino-methyl)-3-(4-chlorophenyl)-propionic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

Reference yield:

: (3S)-3-(4-chlorobenzyl)-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid

: 853681-17-1
(S)-2-(tert-butoxycarbonylamino-methyl)-3-(4-chlorophenyl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 0 - 20 °C

1.2: 5 h / 85 °C

2.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 0 °C

With lithium hydroxide; diphenyl phosphoryl azide; dihydrogen peroxide; triethylamine; In tetrahydrofuran; water; toluene;

Reference yield:

: (3S)-3-(4-chlorobenzyl)-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester

: 853681-17-1
(S)-2-(tert-butoxycarbonylamino-methyl)-3-(4-chlorophenyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 0 - 20 °C

2.2: 5 h / 85 °C

3.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 0 °C

With lithium hydroxide; diphenyl phosphoryl azide; dihydrogen peroxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; toluene;