(S)-5-isobutyl-2-isopropyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:(S)-5-isobutyl-2-isopropyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine
CAS No.:1310693-04-9
Molecular Formula:C₄₉H₄₇N₇
Molecular Weight:733.959
Hs Code.:

Synonyms:(S)-5-isobutyl-2-isopropyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

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Chemical Property of (S)-5-isobutyl-2-isopropyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

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Technology Process of (S)-5-isobutyl-2-isopropyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

There total 7 articles about (S)-5-isobutyl-2-isopropyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1310692-90-0
(S)-3-(5-bromo-2,3-dihydro-1H-inden-1-yl)-5-isobutyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine

: 144873-97-2
2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid

: 1310693-04-9
(S)-5-isobutyl-2-isopropyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 80 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm200409s

Reference yield:

: 1310692-76-2
5-isobutyl-2-isopropyl-7-methyl-3H-imidazo[4,5-b]pyridine

: 1310693-04-9
(S)-5-isobutyl-2-isopropyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Cooling

2: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 18 h / 80 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: Mitsunobu reaction / 2: Suzuki coupling;
DOI:10.1021/jm200409s

Reference yield:

: 1192539-86-8
5-isobutyl-7-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

: 1310693-04-9
(S)-5-isobutyl-2-isopropyl-7-methyl-3-(5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: isobutyric Acid; magnesium chloride / 24 h / 25 - 120 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 25 °C / Inert atmosphere; Cooling

3: palladium diacetate; potassium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 18 h / 80 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; triphenylphosphine; isobutyric Acid; magnesium chloride; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 2: Mitsunobu reaction / 3: Suzuki coupling;
DOI:10.1021/jm200409s