(R)-4-benzyl-3-((R)-2,3-bis(4-methoxyphenyl)propanoyl)oxazolidin-2-one

Base Information

• Chemical Name: (R)-4-benzyl-3-((R)-2,3-bis(4-methoxyphenyl)propanoyl)oxazolidin-2-one
• CAS No.: 1352007-47-6
• Molecular Formula: C₂₇H₂₇NO₅
• Molecular Weight: 445.515
• Mol file: 1352007-47-6.mol

Synonyms:(R)-4-benzyl-3-((R)-2,3-bis(4-methoxyphenyl)propanoyl)oxazolidin-2-one

Chemical Property of (R)-4-benzyl-3-((R)-2,3-bis(4-methoxyphenyl)propanoyl)oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-benzyl-3-((R)-2,3-bis(4-methoxyphenyl)propanoyl)oxazolidin-2-one

There total 1 articles about (R)-4-benzyl-3-((R)-2,3-bis(4-methoxyphenyl)propanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.1%

p-Methoxybenzyl bromide (2746-25-0) + (R)-4-benzyl-3-(2-(4-methoxyphenyl)acetyl)oxazolidin-2-one (143590-12-9) → (R)-4-benzyl-3-((R)-2,3-bis(4-methoxyphenyl)propanoyl)oxazolidin-2-one (1352007-47-6)

Guidance literature:

(R)-4-benzyl-3-(2-(4-methoxyphenyl)acetyl)oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

p-Methoxybenzyl bromide; In tetrahydrofuran; at -78 - 20 ℃; for 5h; optical yield given as %de; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jm201436k

Reference yield: 98.4%

(R)-4-benzyl-3-((R)-2,3-bis(4-methoxyphenyl)propanoyl)oxazolidin-2-one (1352007-47-6) → 2-(4-methoxyphenyl)-3-(4-methoxyphenyl)propionic acid

Guidance literature:

With water; dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm201436k

Reference yield:

(R)-4-benzyl-3-((R)-2,3-bis(4-methoxyphenyl)propanoyl)oxazolidin-2-one (1352007-47-6) → C22H26O6

Guidance literature:

Multi-step reaction with 2 steps

1: water; dihydrogen peroxide; lithium hydroxide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

With water; dihydrogen peroxide; triethylamine; lithium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm201436k

upstream raw materials:

p-Methoxybenzyl bromide

(R)-4-benzyl-3-(2-(4-methoxyphenyl)acetyl)oxazolidin-2-one

Downstream raw materials:

(R)-DPN