4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methylpyrimidine-4,5,6-triamine

Base Information

• Chemical Name: 4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methylpyrimidine-4,5,6-triamine
• CAS No.: 220953-47-9
• Molecular Formula: C₁₉H₂₈BrN₅O₄
• Molecular Weight: 470.366

Synonyms:4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methylpyrimidine-4,5,6-triamine

Chemical Property of 4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methylpyrimidine-4,5,6-triamine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methylpyrimidine-4,5,6-triamine

There total 4 articles about 4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methylpyrimidine-4,5,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methyl-5-nitropyrimidine-4,6-diamine (220953-33-3) → 4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methylpyrimidine-4,5,6-triamine (220953-47-9)

Guidance literature:

With ammonium hydroxide; sodium dithionite; In 1,4-dioxane; water; at 25 ℃;

DOI:10.1021/jm980224g

Reference yield:

Bis-(2-methoxyethyl)amine (111-95-5) → 4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methylpyrimidine-4,5,6-triamine (220953-47-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / Et₃N / ethanol / 1 h / Ambient temperature

2: 64 percent / dimethylformamide / 144 h / 60 °C

3: 72 percent / Na₂S₂O₄, NH₄OH / dioxane; H₂O / 25 °C

With ammonium hydroxide; sodium dithionite; triethylamine; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm980224g

Reference yield:

4,6-dichloro-2-methyl-5-nitropyrimidine (13162-43-1) → 4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methylpyrimidine-4,5,6-triamine (220953-47-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / Et₃N / ethanol / 1 h / Ambient temperature

2: 64 percent / dimethylformamide / 144 h / 60 °C

3: 72 percent / Na₂S₂O₄, NH₄OH / dioxane; H₂O / 25 °C

With ammonium hydroxide; sodium dithionite; triethylamine; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm980224g

upstream raw materials:

4-N-bis(2-methoxyethyl)-6-N-(2-bromo-4,6-dimethoxyphenyl)-2-methyl-5-nitropyrimidine-4,6-diamine

Bis-(2-methoxyethyl)amine

4,6-dichloro-2-methyl-5-nitropyrimidine

4-N-bis(2-methoxyethyl)-6-chloro-2-methyl-5-nitropyrimidin-4-amine

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