(S)-4,5-dihydro-2-[2-hydroxy-3-(3,6-dioxaheptyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid

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Chemical Name:(S)-4,5-dihydro-2-[2-hydroxy-3-(3,6-dioxaheptyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid
CAS No.:1204751-09-6
Molecular Formula:C₁₆H₂₁NO₆S
Molecular Weight:355.412
Hs Code.:

Synonyms:(S)-4,5-dihydro-2-[2-hydroxy-3-(3,6-dioxaheptyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid

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Chemical Property of (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6-dioxaheptyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid

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Technology Process of (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6-dioxaheptyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid

There total 2 articles about (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6-dioxaheptyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1346427-97-1
2-hydroxy-3-(3,6-dioxaheptyloxy)benzonitrile

: (S)-α-methylcysteine hydrochloride

: 1204751-09-6
(S)-4,5-dihydro-2-[2-hydroxy-3-(3,6-dioxaheptyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: With sodium hydrogencarbonate; In methanol; at 70 ℃; pH=6.2 - 6.6; aq. phosphate buffer;
DOI:10.1007/s10534-010-9389-y

Reference yield:

: 67984-81-0
2,3-dihydroxybenzonitrile

: 50586-80-6,58320-73-3
toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester

: 1204751-09-6
(S)-4,5-dihydro-2-[2-hydroxy-3-(3,6-dioxaheptyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C

1.2: 24 h / 20 °C

2.1: sodium hydrogencarbonate / methanol / 70 °C / pH 6.2 - 6.6 / aq. phosphate buffer

With sodium hydride; sodium hydrogencarbonate; In methanol; dimethyl sulfoxide;
DOI:10.1007/s10534-010-9389-y