5-(6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1333338-04-7
Molecular Formula:C₃₆H₃₀FN₃O₅S
Molecular Weight:635.716
Hs Code.:

Synonyms:5-(6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 16 articles about 5-(6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.6%

: 1333337-10-2
5-(12-chloro-6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 1333338-04-7
5-(6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; for 15h; under 2585.81 Torr;

Reference yield:

: 1426960-51-1
4-bromo-2-(3-chloro-1H-indol-2-yl)phenol

: 1333338-04-7
5-(6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / 0.15 h / 110 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 0.15 h / 90 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate trihydrate / N,N-dimethyl-formamide / 0.33 h / 100 °C / Sealed tube; Microwave irradiation

4: palladium on activated charcoal; hydrogen / methanol / 15 h / 2585.81 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate trihydrate; palladium on activated charcoal; hydrogen; potassium acetate; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1426960-52-2
2-bromo-12-chloro-6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole

: 1333338-04-7
5-(6-cyclopropyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 0.15 h / 90 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate trihydrate / N,N-dimethyl-formamide / 0.33 h / 100 °C / Sealed tube; Microwave irradiation

3: palladium on activated charcoal; hydrogen / methanol / 15 h / 2585.81 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate trihydrate; palladium on activated charcoal; hydrogen; potassium acetate; In methanol; N,N-dimethyl-formamide;