(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-carbamoylmethyl-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

Base Information

Chemical Name:(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-carbamoylmethyl-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide
CAS No.:97280-28-9
Molecular Formula:BrH*2C₂₇H₃₂N₆O₇
Molecular Weight:1186.09
Hs Code.:

(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-carbamoylmethyl-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

Synonyms:(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-carbamoylmethyl-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

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Chemical Property of (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-carbamoylmethyl-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

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Technology Process of (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-carbamoylmethyl-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

There total 2 articles about (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-carbamoylmethyl-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 77766-62-2
2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

: 80014-83-1
diethyl N-<4-<(carbamoylmethyl)amino>benzoyl>-L-glutamate

: 97280-28-9
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-carbamoylmethyl-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

Guidance literature:: With calcium carbonate; In N,N-dimethyl acetamide; at 25 ℃; for 60h;
DOI:10.1021/jm00148a016

Reference yield:

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 97280-28-9
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-carbamoylmethyl-amino]-benzoylamino}-pentanedioic acid diethyl ester; hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / 2,6-lutidine / N,N-dimethyl-acetamide / 4 h / 110 °C

2: 30 percent / CaCO₃ / N,N-dimethyl-acetamide / 60 h / 25 °C

With 2,6-dimethylpyridine; calcium carbonate; In N,N-dimethyl acetamide;
DOI:10.1021/jm00148a016