(1R,2R,4R)-N-benzyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine

Base Information

• Chemical Name: (1R,2R,4R)-N-benzyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine
• CAS No.: 158411-96-2
• Molecular Formula: C₁₇H₂₅N
• Molecular Weight: 243.392
• Mol file: 158411-96-2.mol

Synonyms:(1R,2R,4R)-N-benzyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine

Chemical Property of (1R,2R,4R)-N-benzyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,4R)-N-benzyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine

There total 10 articles about (1R,2R,4R)-N-benzyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (464-49-3,68546-28-1) + benzylamine (100-46-9) → (1R,2R,4R)-N-benzyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine (158411-96-2)

Guidance literature:

With iron pentacarbonyl; In neat (no solvent); at 120 ℃; for 14h; stereoselective reaction; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1002/ejoc.202001087

Reference yield:

N-(benzyl)-(D)-camphorimine (63765-03-7,145771-06-8) → (1R,2R,4R)-N-benzyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine (158411-96-2)

Guidance literature:

With tris(pentafluorophenyl)borate; hydrogen; In toluene; at 115 ℃; for 120h; under 3800.26 Torr; optical yield given as %de; diastereoselective reaction;

DOI:10.1039/c1cc10438a

Reference yield:

C17H23N → (1R,2R,4R)-N-benzyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine (158411-96-2)

Guidance literature:

With borohydride; In methanol; Inert atmosphere;

DOI:10.1016/j.tetasy.2017.08.007

upstream raw materials:

(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

N-(benzyl)-(D)-camphorimine

benzylamine

exo-bornylamine