methyl (R)-2-((S)-2-(5-(7-(2-((S)-1-((S)-2-methoxycarbonylamino-3-methylbutanoyI)pyrrolidm-2-yI)-1H-benzo[d]imidazol-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate

Base Information

Chemical Name:methyl (R)-2-((S)-2-(5-(7-(2-((S)-1-((S)-2-methoxycarbonylamino-3-methylbutanoyI)pyrrolidm-2-yI)-1H-benzo[d]imidazol-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate
CAS No.:1377040-19-1
Molecular Formula:C₄₇H₄₈N₈O₆S
Molecular Weight:853.014
Hs Code.:

methyl (R)-2-((S)-2-(5-(7-(2-((S)-1-((S)-2-methoxycarbonylamino-3-methylbutanoyI)pyrrolidm-2-yI)-1H-benzo[d]imidazol-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate

Synonyms:methyl (R)-2-((S)-2-(5-(7-(2-((S)-1-((S)-2-methoxycarbonylamino-3-methylbutanoyI)pyrrolidm-2-yI)-1H-benzo[d]imidazol-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate

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Chemical Property of methyl (R)-2-((S)-2-(5-(7-(2-((S)-1-((S)-2-methoxycarbonylamino-3-methylbutanoyI)pyrrolidm-2-yI)-1H-benzo[d]imidazol-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate

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Technology Process of methyl (R)-2-((S)-2-(5-(7-(2-((S)-1-((S)-2-methoxycarbonylamino-3-methylbutanoyI)pyrrolidm-2-yI)-1H-benzo[d]imidazol-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate

There total 6 articles about methyl (R)-2-((S)-2-(5-(7-(2-((S)-1-((S)-2-methoxycarbonylamino-3-methylbutanoyI)pyrrolidm-2-yI)-1H-benzo[d]imidazol-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1378383-23-3
(S)-benzyl 2-(5-(7-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-benzo[d]imidazol-6-yI)-dibenzo[b,d]thiophen-3-yI)-1H-imidazol-2-yl)pyrrolidine-l-carboxylate

: 50890-96-5
(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid

: 1377040-19-1
methyl (R)-2-((S)-2-(5-(7-(2-((S)-1-((S)-2-methoxycarbonylamino-3-methylbutanoyI)pyrrolidm-2-yI)-1H-benzo[d]imidazol-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate

Guidance literature:: (S)-benzyl 2-(5-(7-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-benzo[d]imidazol-6-yI)-dibenzo[b,d]thiophen-3-yI)-1H-imidazol-2-yl)pyrrolidine-l-carboxylate; With hydrogen; potassium carbonate; palladium 10% on activated carbon; In ethanol; water; for 18h; Inert atmosphere;

(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid; With COMU; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

: 1378383-22-2
(S)-benzyl 2-(5-(7-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-benzo[d]imidazoI-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazoI-2-yl)pyrrolidine-1-carboxylate

: 1377040-19-1
methyl (R)-2-((S)-2-(5-(7-(2-((S)-1-((S)-2-methoxycarbonylamino-3-methylbutanoyI)pyrrolidm-2-yI)-1H-benzo[d]imidazol-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol; water / 1 h / 60 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: potassium carbonate; hydrogen / palladium 10% on activated carbon / ethanol; water / 18 h / Inert atmosphere

3.2: 1 h / 0 °C

With hydrogenchloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1378383-25-5
C₃₈H₃₄N₆O₂S

: 1377040-19-1
methyl (R)-2-((S)-2-(5-(7-(2-((S)-1-((S)-2-methoxycarbonylamino-3-methylbutanoyI)pyrrolidm-2-yI)-1H-benzo[d]imidazol-6-yl)dibenzo[b,d]thiophen-3-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: potassium carbonate; hydrogen / palladium 10% on activated carbon / ethanol; water / 18 h / Inert atmosphere

2.2: 1 h / 0 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide;